Assay Detail
Functional
CHEMBL712541
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The in vitro leishmanicidal activity by measuring the 3H thymidine incorporation in promastigotes of Leishmania donovani
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Leishmania donovani |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Functionalized azoles and triazolo[1,5-a]pyrimidines as latent leishmanicides
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.50 | 6.12 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL55 | PENTAMIDINE | 4.0 | 1 | 6.12 |
| CHEMBL11836 | — | — | 1 | 5.82 |
| CHEMBL269225 | — | — | 1 | 5.70 |
| CHEMBL11624 | — | — | 1 | 5.70 |
| CHEMBL11757 | — | — | 1 | 5.70 |
| CHEMBL11875 | — | — | 1 | 5.19 |
| CHEMBL11886 | — | — | 1 | 4.98 |
| CHEMBL11835 | — | — | 1 | 4.81 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL55 | PENTAMIDINE | IC50 | = | 760.0 | nM | 6.12 |
| CHEMBL11836 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL269225 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL11624 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL11757 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL11875 | — | IC50 | = | 6400.0 | nM | 5.19 |
| CHEMBL11886 | — | IC50 | = | 10500.0 | nM | 4.98 |
| CHEMBL11835 | — | IC50 | = | 15500.0 | nM | 4.81 |