Assay Detail

CHEMBL712582

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional

Cytotoxic potentiation of Topotecan (TP) by the compound in (human colorectal cancer LoVo cell line

ChEMBL ↗

Free Research Context This assay will appear in recent viewed items on this browser. Open the demo workspace to preview project-only review queues.

Research home Demo workspace

Target

LoVo (CHEMBL614721) ↗

Open DB target context

Use one target anchor to keep assay intent, target linkage, and tested compound review aligned.

Loading context

LoVo (CHEMBL614721) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target LoVo

CHEMBL614721

Anchored from Assay target.

Protein identity LoVo

Disease frame Disease evidence pending

Open the live target snapshot or evidence card before reviewing assay metadata so target fit and disease framing stay reusable.

Review focus Open DB context pending

Open the live target snapshot before relying on this target frame across surface handoff.

Open target snapshot Open evidence card Search with this context

Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Homo sapiens
Cell Type	LoVo
Confidence	1 — Organism
Curated By	Intermediate

Target

LoVo (CHEMBL614721) ↗

Type	CELL-LINE
Organism	Homo sapiens

Publication

Novel tricyclic poly(ADP-ribose) polymerase-1 inhibitors with potent anticancer chemopotentiating activity: design, synthesis, and X-ray cocrystal structure.

Canan Koch SS, Thoresen LH, Tikhe JG, Maegley KA, Almassy RJ, Li J, Yu XH, Zook SE, Kumpf RA, Zhang C, Boritzki TJ, Mansour RN, Zhang KE, Ekker A, Calabrese CR, Curtin NJ, Kyle S, Thomas HD, Wang LZ, Calvert AH, Golding BT, Griffin RJ, Newell DR, Webber SE, Hostomsky Z.
J Med Chem (2002) 45 : 4961 -4974
PubMed 12408707 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	2	7.94	7.94

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL84	TOPOTECAN	4.0	1	7.94
CHEMBL810	TEMOZOLOMIDE	4.0	1	-

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL84	TOPOTECAN	IC50	=	11.6	nM	7.94
CHEMBL810	TEMOZOLOMIDE	IC50	=	595000.0	nM	-