Assay Detail
Functional
CHEMBL712586
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Inhibition of human adenocarcinoma cell line LoVo proliferation
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | LoVo |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Aldisine alkaloids from the Philippine sponge Stylissa massa are potent inhibitors of mitogen-activated protein kinase kinase-1 (MEK-1).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 6.56 | 7.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL54044 | — | — | 1 | 7.30 |
| CHEMBL359106 | — | — | 1 | 6.23 |
| CHEMBL361708 | HYMENIALDISINE | — | 1 | 6.15 |
| CHEMBL397591 | OROIDIN | — | 1 | - |
| CHEMBL356164 | — | — | 1 | - |
| CHEMBL255465 | DEBROMOHYMENIALDISINE | — | 1 | - |
| CHEMBL151430 | — | — | 1 | - |
| CHEMBL357047 | ALDISIN | — | 1 | - |
| CHEMBL440356 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL54044 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL359106 | — | IC50 | = | 586.0 | nM | 6.23 |
| CHEMBL361708 | HYMENIALDISINE | IC50 | = | 710.0 | nM | 6.15 |
| CHEMBL397591 | OROIDIN | IC50 | > | 10000.0 | nM | - |
| CHEMBL356164 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL255465 | DEBROMOHYMENIALDISINE | IC50 | > | 10000.0 | nM | - |
| CHEMBL151430 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL357047 | ALDISIN | IC50 | > | 10000.0 | nM | - |
| CHEMBL440356 | — | IC50 | > | 10000.0 | nM | - |