Assay Detail
Functional
CHEMBL712691
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Compound was tested for binding affinity against nuclear ER in MCF-7 cell extracts
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MCF7 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Substituted-vinyl hydroxytriarylethylenes, 1-[4-[2-(diethylamino) ethoxy]phenyl]-1-(4-hydroxyphenyl)-2-phenylethylenes: synthesis and effects on MCF 7 breast cancer cell proliferation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 6 | 9.35 | 9.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1056 | 4-OH-ENCLOMIPHENE | -1.0 | 1 | 9.96 |
| CHEMBL84390 | — | — | 1 | 9.54 |
| CHEMBL85675 | — | — | 1 | 9.44 |
| CHEMBL82159 | — | — | 1 | 9.25 |
| CHEMBL63877 | — | — | 1 | 8.96 |
| CHEMBL83562 | — | — | 1 | 8.96 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1056 | 4-OH-ENCLOMIPHENE | Kd | = | 0.11 | nM | 9.96 |
| CHEMBL84390 | — | Kd | = | 0.29 | nM | 9.54 |
| CHEMBL85675 | — | Kd | = | 0.36 | nM | 9.44 |
| CHEMBL82159 | — | Kd | = | 0.56 | nM | 9.25 |
| CHEMBL63877 | — | Kd | = | 1.11 | nM | 8.96 |
| CHEMBL83562 | — | Kd | = | 1.11 | nM | 8.96 |