Assay Detail
Binding
CHEMBL712809
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Inhibition of MMP-3 (human fibroblast stromelysin)
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Macrocyclic hydroxamate inhibitors of matrix metalloproteinases and TNF-alpha production.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 7.78 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL23725 | — | — | 1 | 8.52 |
| CHEMBL24761 | — | — | 1 | 8.47 |
| CHEMBL283427 | — | — | 1 | 7.92 |
| CHEMBL277658 | — | — | 1 | 7.82 |
| CHEMBL24347 | — | — | 1 | 7.00 |
| CHEMBL283429 | — | — | 1 | 6.93 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL23725 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL24761 | — | Ki | = | 3.4 | nM | 8.47 |
| CHEMBL283427 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL277658 | — | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL24347 | — | Ki | = | 99.0 | nM | 7.00 |
| CHEMBL283429 | — | Ki | = | 118.0 | nM | 6.93 |