Assay Detail
Functional
CHEMBL712883
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Antagonistic activity against metabotropic glutamate receptor 8 (mGluR8) was evaluated
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
2,3'-disubstituted-2-(2'-carboxycyclopropyl)glycines as potent and selective antagonists of metabotropic glutamate receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 6.05 | 6.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL432038 | — | — | 1 | 6.77 |
| CHEMBL329920 | — | — | 1 | 6.47 |
| CHEMBL97200 | — | — | 1 | 6.42 |
| CHEMBL95868 | — | — | 1 | 6.31 |
| CHEMBL319732 | — | — | 1 | 6.12 |
| CHEMBL319279 | — | — | 1 | 6.00 |
| CHEMBL97574 | — | — | 1 | 5.91 |
| CHEMBL99462 | — | — | 1 | 5.65 |
| CHEMBL439775 | — | — | 1 | 5.60 |
| CHEMBL420262 | — | — | 1 | 5.29 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL432038 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL329920 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL97200 | — | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL95868 | — | IC50 | = | 490.0 | nM | 6.31 |
| CHEMBL319732 | — | IC50 | = | 750.0 | nM | 6.12 |
| CHEMBL319279 | — | IC50 | = | 990.0 | nM | 6.00 |
| CHEMBL97574 | — | IC50 | = | 1230.0 | nM | 5.91 |
| CHEMBL99462 | — | IC50 | = | 2250.0 | nM | 5.65 |
| CHEMBL439775 | — | IC50 | = | 2520.0 | nM | 5.60 |
| CHEMBL420262 | — | IC50 | = | 5180.0 | nM | 5.29 |