Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL712893

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of metallo-beta-lactamase (MBL) from Bacteroides fragilis.
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Bacteroides fragilis
Confidence 9 — Direct single protein target
Curated By Intermediate

Target

Metallo-beta-lactamase type 2 (CHEMBL4840)
Type SINGLE PROTEIN
Organism Bacteroides fragilis

Publication

Structure-activity relationships of biphenyl tetrazoles as metallo-beta-lactamase inhibitors.
Toney JH, Cleary KA, Hammond GG, Yuan X, May WJ, Hutchins SM, Ashton WT, Vanderwall DE.
Bioorg Med Chem Lett (1999) 9 : 2741 -2746
PubMed 10509927 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 25 4.25 4.75

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL327718 1 4.75
CHEMBL327862 1 4.66
CHEMBL93226 1 4.52
CHEMBL90774 1 4.48
CHEMBL94002 1 4.43
CHEMBL92654 1 4.40
CHEMBL315878 1 4.30
CHEMBL93735 1 4.16
CHEMBL92472 1 4.10
CHEMBL328598 1 4.10
CHEMBL90011 1 4.10
CHEMBL419321 1 4.00
CHEMBL329541 1 4.00
CHEMBL327837 1 4.00
CHEMBL329466 1 4.00
CHEMBL329616 1 4.00
CHEMBL330571 1 -
CHEMBL327982 1 -
CHEMBL93886 1 -
CHEMBL91287 1 -
CHEMBL406791 1 -
CHEMBL92821 1 -
CHEMBL94221 1 -
CHEMBL93547 1 -
CHEMBL93289 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL327718 IC50 = 18000.0 nM 4.75
CHEMBL327862 IC50 = 22000.0 nM 4.66
CHEMBL93226 IC50 = 30000.0 nM 4.52
CHEMBL90774 IC50 = 33000.0 nM 4.48
CHEMBL94002 IC50 = 37000.0 nM 4.43
CHEMBL92654 IC50 = 40000.0 nM 4.40
CHEMBL315878 IC50 = 50000.0 nM 4.30
CHEMBL93735 IC50 = 70000.0 nM 4.16
CHEMBL92472 IC50 = 80000.0 nM 4.10
CHEMBL328598 IC50 = 80000.0 nM 4.10
CHEMBL90011 IC50 = 80000.0 nM 4.10
CHEMBL419321 IC50 = 100000.0 nM 4.00
CHEMBL329541 IC50 = 100000.0 nM 4.00
CHEMBL327837 IC50 = 100000.0 nM 4.00
CHEMBL329466 IC50 = 100000.0 nM 4.00
CHEMBL329616 IC50 = 100000.0 nM 4.00
CHEMBL330571 IC50 = 190000.0 nM -
CHEMBL327982 IC50 = 200000.0 nM -
CHEMBL93886 IC50 = 180000.0 nM -
CHEMBL91287 IC50 = 290000.0 nM -
CHEMBL406791 IC50 > 200000.0 nM -
CHEMBL92821 IC50 = 170000.0 nM -
CHEMBL94221 IC50 = 230000.0 nM -
CHEMBL93547 IC50 = 120000.0 nM -
CHEMBL93289 IC50 = 170000.0 nM -