Assay Detail
Functional
CHEMBL712919
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antitumor activity against human mammary carcinoma doxorubicin-resistant MXF7 breast cell line.
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MCF7 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
2-[2'-(Dimethylamino)ethyl]-1,2-dihydro- 3H-dibenz[de,h]isoquinoline-1,3-diones with substituents at positions 4, 8, 9, 10, and 11. Synthesis, antitumor activity, and quantitative structure-activity relationships.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 25 | 7.01 | 8.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL148281 | — | — | 1 | 8.10 |
| CHEMBL343913 | — | — | 1 | 8.06 |
| CHEMBL144014 | — | — | 1 | 7.70 |
| CHEMBL147372 | — | — | 1 | 7.70 |
| CHEMBL146785 | — | — | 1 | 7.60 |
| CHEMBL146516 | — | — | 1 | 7.46 |
| CHEMBL356797 | — | — | 1 | 7.30 |
| CHEMBL422137 | — | — | 1 | 7.28 |
| CHEMBL149184 | — | — | 1 | 7.23 |
| CHEMBL149293 | — | — | 1 | 7.17 |
| CHEMBL290677 | AZONAFIDE | — | 1 | 7.16 |
| CHEMBL148344 | — | — | 1 | 7.15 |
| CHEMBL58 | MITOXANTRONE | 4.0 | 1 | 7.14 |
| CHEMBL344310 | — | — | 1 | 7.10 |
| CHEMBL147576 | — | — | 1 | 7.00 |
| CHEMBL439812 | — | — | 1 | 6.92 |
| CHEMBL356785 | — | — | 1 | 6.85 |
| CHEMBL147428 | — | — | 1 | 6.72 |
| CHEMBL439632 | — | — | 1 | 6.70 |
| CHEMBL146559 | — | — | 1 | 6.64 |
| CHEMBL343852 | — | — | 1 | 6.28 |
| CHEMBL358993 | — | — | 1 | 6.16 |
| CHEMBL148229 | — | — | 1 | 6.15 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 5.93 |
| CHEMBL428676 | AMONAFIDE | 3.0 | 1 | 5.75 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL148281 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL343913 | — | IC50 | = | 8.7 | nM | 8.06 |
| CHEMBL144014 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL147372 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL146785 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL146516 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL356797 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL422137 | — | IC50 | = | 52.0 | nM | 7.28 |
| CHEMBL149184 | — | IC50 | = | 59.0 | nM | 7.23 |
| CHEMBL149293 | — | IC50 | = | 67.0 | nM | 7.17 |
| CHEMBL290677 | AZONAFIDE | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL148344 | — | IC50 | = | 71.0 | nM | 7.15 |
| CHEMBL58 | MITOXANTRONE | IC50 | = | 72.0 | nM | 7.14 |
| CHEMBL344310 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL147576 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL439812 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL356785 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL147428 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL439632 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL146559 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL343852 | — | IC50 | = | 530.0 | nM | 6.28 |
| CHEMBL358993 | — | IC50 | = | 690.0 | nM | 6.16 |
| CHEMBL148229 | — | IC50 | = | 710.0 | nM | 6.15 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 1172.0 | nM | 5.93 |
| CHEMBL428676 | AMONAFIDE | IC50 | = | 1800.0 | nM | 5.75 |