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Assay Detail

CHEMBL712992

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibitory activity against malate dehydrogenase (MDH) from Thermus flavus
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Thermus thermophilus
Confidence 9 — Direct single protein target
Curated By Expert

Target

Malate dehydrogenase (CHEMBL4255)
Type SINGLE PROTEIN
Organism Thermus thermophilus

Publication

Kinase inhibitors: not just for kinases anymore.
McGovern SL, Shoichet BK.
J Med Chem (2003) 46 : 1478 -1483
PubMed 12672248 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 13 4.69 6.16

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL34241 ROTTLERIN 1 6.16
CHEMBL50 QUERCETIN 3.0 1 5.22
CHEMBL16958 STAUROSPORINONE 1 5.10
CHEMBL34034 1 4.60
CHEMBL1160008 IODOPHTHALEIN 2.0 1 4.60
CHEMBL1276127 INDIRUBIN 2.0 1 4.52
CHEMBL34712 1 4.52
CHEMBL6291 BISINDOLYLMALEIMIDE IX 1 4.35
CHEMBL1160010 1 4.30
CHEMBL599552 INDIGO 3.0 1 4.22
CHEMBL34704 1 4.00
CHEMBL268769 1 -
CHEMBL430923 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL34241 ROTTLERIN IC50 = 700.0 nM 6.16
CHEMBL50 QUERCETIN IC50 = 6000.0 nM 5.22
CHEMBL16958 STAUROSPORINONE IC50 = 8000.0 nM 5.10
CHEMBL34034 IC50 = 25000.0 nM 4.60
CHEMBL1160008 IODOPHTHALEIN IC50 = 25000.0 nM 4.60
CHEMBL1276127 INDIRUBIN IC50 = 30000.0 nM 4.52
CHEMBL34712 IC50 = 30000.0 nM 4.52
CHEMBL6291 BISINDOLYLMALEIMIDE IX IC50 = 45000.0 nM 4.35
CHEMBL1160010 IC50 = 50000.0 nM 4.30
CHEMBL599552 INDIGO IC50 = 60000.0 nM 4.22
CHEMBL34704 IC50 = 100000.0 nM 4.00
CHEMBL268769 IC50 > 400000.0 nM -
CHEMBL430923 IC50 = 120000.0 nM -