Assay Detail
Binding
CHEMBL713016
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Binding affinity against human Melanocortin 5 receptor
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Structure-activity studies of the melanocortin peptides: discovery of potent and selective affinity antagonists for the hMC3 and hMC4 receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 9 | 8.38 | 10.51 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1161313 | — | — | 1 | 10.51 |
| CHEMBL2096742 | — | — | 1 | 9.92 |
| CHEMBL1161323 | — | — | 1 | 9.70 |
| CHEMBL1161318 | — | — | 1 | 8.00 |
| CHEMBL1161321 | — | — | 1 | 7.77 |
| CHEMBL415333 | — | — | 1 | 7.38 |
| CHEMBL1161316 | — | — | 1 | 7.35 |
| CHEMBL1161320 | — | — | 1 | 6.41 |
| CHEMBL2372588 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1161313 | — | EC50 | = | 0.031 | nM | 10.51 |
| CHEMBL2096742 | — | EC50 | = | 0.12 | nM | 9.92 |
| CHEMBL1161323 | — | EC50 | = | 0.2 | nM | 9.70 |
| CHEMBL1161318 | — | EC50 | = | 10.0 | nM | 8.00 |
| CHEMBL1161321 | — | EC50 | = | 17.0 | nM | 7.77 |
| CHEMBL415333 | — | EC50 | = | 42.0 | nM | 7.38 |
| CHEMBL1161316 | — | EC50 | = | 45.0 | nM | 7.35 |
| CHEMBL1161320 | — | EC50 | = | 390.0 | nM | 6.41 |
| CHEMBL2372588 | — | EC50 | > | 100.0 | nM | - |