Assay Detail
Functional
CHEMBL713021
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Effective concentration that was able to generate 50% maximal intracellular cAMP in L-cells transfected with Melanocortin 5 receptor
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Biological and conformational examination of stereochemical modifications using the template melanotropin peptide, Ac-Nle-c[Asp-His-Phe-Arg-Trp-Ala-Lys]-NH2, on human melanocortin receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 8.22 | 9.24 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL441738 | AFAMELANOTIDE | 4.0 | 1 | 9.24 |
| CHEMBL430239 | MELATONAN | — | 1 | 8.83 |
| CHEMBL2115441 | — | — | 1 | 8.22 |
| CHEMBL3350396 | — | — | 1 | 6.57 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL441738 | AFAMELANOTIDE | EC50 | = | 0.58 | nM | 9.24 |
| CHEMBL430239 | MELATONAN | EC50 | = | 1.48 | nM | 8.83 |
| CHEMBL2115441 | — | EC50 | = | 6.01 | nM | 8.22 |
| CHEMBL3350396 | — | EC50 | = | 269.0 | nM | 6.57 |