Assay Detail
Functional
CHEMBL713022
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Effective concentration required for intracellular cAMP accumulation by Melanocortin 5 receptor
10
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
D-Amino acid scan of gamma-melanocyte-stimulating hormone: importance of Trp(8) on human MC3 receptor selectivity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 10 | 6.54 | 9.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL441738 | AFAMELANOTIDE | 4.0 | 1 | 9.64 |
| CHEMBL3349030 | — | — | 5 | 7.31 |
| CHEMBL405282 | — | — | 1 | 7.09 |
| CHEMBL437050 | — | — | 1 | 6.31 |
| CHEMBL410795 | — | — | 1 | 6.26 |
| CHEMBL2112008 | — | — | 1 | 5.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL441738 | AFAMELANOTIDE | EC50 | = | 0.23 | nM | 9.64 |
| CHEMBL3349030 | — | EC50 | = | 49.0 | nM | 7.31 |
| CHEMBL405282 | — | EC50 | = | 82.0 | nM | 7.09 |
| CHEMBL437050 | — | EC50 | = | 490.0 | nM | 6.31 |
| CHEMBL410795 | — | EC50 | = | 550.0 | nM | 6.26 |
| CHEMBL3349030 | — | EC50 | = | 770.0 | nM | 6.11 |
| CHEMBL3349030 | — | EC50 | = | 810.0 | nM | 6.09 |
| CHEMBL3349030 | — | EC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL3349030 | — | EC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL2112008 | — | EC50 | = | 5000.0 | nM | 5.30 |