Assay Detail
Binding
CHEMBL713029
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Binding affinity for Human Melanocortin 5 receptor expressed in L-cells
12
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
D-Amino acid scan of gamma-melanocyte-stimulating hormone: importance of Trp(8) on human MC3 receptor selectivity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 6.18 | 9.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL441738 | AFAMELANOTIDE | 4.0 | 1 | 9.05 |
| CHEMBL3349030 | — | — | 7 | 7.11 |
| CHEMBL405282 | — | — | 1 | 6.47 |
| CHEMBL410795 | — | — | 1 | 6.27 |
| CHEMBL437050 | — | — | 1 | 5.60 |
| CHEMBL2112008 | — | — | 1 | 5.15 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL441738 | AFAMELANOTIDE | IC50 | = | 0.89 | nM | 9.05 |
| CHEMBL3349030 | — | IC50 | = | 77.0 | nM | 7.11 |
| CHEMBL405282 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL3349030 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL410795 | — | IC50 | = | 540.0 | nM | 6.27 |
| CHEMBL3349030 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL3349030 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL437050 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL3349030 | — | IC50 | = | 5700.0 | nM | 5.24 |
| CHEMBL2112008 | — | IC50 | = | 7100.0 | nM | 5.15 |
| CHEMBL3349030 | — | IC50 | = | 8500.0 | nM | 5.07 |
| CHEMBL3349030 | — | IC50 | > | 10000.0 | nM | - |