Assay Detail
Binding
CHEMBL713030
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity against human Melanocortin 5 receptor
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Structure-activity studies of the melanocortin peptides: discovery of potent and selective affinity antagonists for the hMC3 and hMC4 receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 8.72 | 10.57 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1161313 | — | — | 1 | 10.57 |
| CHEMBL2096742 | — | — | 1 | 10.05 |
| CHEMBL1161323 | — | — | 1 | 9.96 |
| CHEMBL1161320 | — | — | 1 | 8.39 |
| CHEMBL1161318 | — | — | 1 | 8.34 |
| CHEMBL1161321 | — | — | 1 | 7.92 |
| CHEMBL415333 | — | — | 1 | 7.80 |
| CHEMBL1161316 | — | — | 1 | 7.80 |
| CHEMBL2372588 | — | — | 1 | 7.68 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1161313 | — | IC50 | = | 0.027 | nM | 10.57 |
| CHEMBL2096742 | — | IC50 | = | 0.09 | nM | 10.05 |
| CHEMBL1161323 | — | IC50 | = | 0.11 | nM | 9.96 |
| CHEMBL1161320 | — | IC50 | = | 4.1 | nM | 8.39 |
| CHEMBL1161318 | — | IC50 | = | 4.6 | nM | 8.34 |
| CHEMBL1161321 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL415333 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL1161316 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL2372588 | — | IC50 | = | 21.0 | nM | 7.68 |