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Assay Detail

CHEMBL713341

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Cytotoxicity against human melanoma MM96L cell line
ChEMBL ↗
42
Total Activities
37
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type MM96L
Confidence 1 — Organism
Curated By Expert

Target

MM96L (CHEMBL614170) ↗
Type CELL-LINE
Organism Homo sapiens

Publication

Antiproliferative and phenotype-transforming antitumor agents derived from cysteine.
Glenn MP, Kahnberg P, Boyle GM, Hansford KA, Hans D, Martyn AC, Parsons PG, Fairlie DP.
J Med Chem (2004) 47 : 2984 -2994
PubMed 15163181 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 42 5.60 7.52

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL99 TRICHOSTATIN 1.0 2 7.52
CHEMBL101006 — — 2 6.89
CHEMBL318384 — — 2 6.85
CHEMBL103508 — — 2 6.70
CHEMBL103379 — — 2 6.70
CHEMBL323346 — — 1 6.22
CHEMBL103556 — — 1 6.05
CHEMBL101163 — — 1 5.77
CHEMBL322871 — — 1 5.75
CHEMBL101295 — — 1 5.70
CHEMBL322691 — — 1 5.60
CHEMBL103545 — — 1 5.39
CHEMBL420648 — — 1 5.36
CHEMBL323076 — — 1 5.30
CHEMBL99912 — — 1 5.30
CHEMBL100055 — — 1 5.28
CHEMBL328619 — — 1 5.20
CHEMBL322899 — — 1 5.16
CHEMBL318731 — — 1 5.14
CHEMBL103509 — — 1 5.13
CHEMBL410117 — — 1 5.10
CHEMBL101705 — — 1 5.03
CHEMBL414226 — — 1 4.97
CHEMBL322242 — — 1 4.96
CHEMBL100060 — — 1 4.96
CHEMBL102109 — — 1 4.92
CHEMBL99740 — — 1 4.92
CHEMBL431059 — — 1 4.89
CHEMBL321714 — — 1 4.89
CHEMBL319029 — — 1 4.72

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL99 TRICHOSTATIN IC50 = 30.0 nM 7.52
CHEMBL99 TRICHOSTATIN IC50 = 30.0 nM 7.52
CHEMBL101006 — IC50 = 130.0 nM 6.89
CHEMBL101006 — IC50 = 130.0 nM 6.89
CHEMBL318384 — IC50 = 140.0 nM 6.85
CHEMBL318384 — IC50 = 140.0 nM 6.85
CHEMBL103508 — IC50 = 200.0 nM 6.70
CHEMBL103508 — IC50 = 200.0 nM 6.70
CHEMBL103379 — IC50 = 200.0 nM 6.70
CHEMBL103379 — IC50 = 200.0 nM 6.70
CHEMBL323346 — IC50 = 600.0 nM 6.22
CHEMBL103556 — IC50 = 900.0 nM 6.05
CHEMBL101163 — IC50 = 1700.0 nM 5.77
CHEMBL322871 — IC50 = 1800.0 nM 5.75
CHEMBL101295 — IC50 = 2000.0 nM 5.70
CHEMBL322691 — IC50 = 2500.0 nM 5.60
CHEMBL103545 — IC50 = 4100.0 nM 5.39
CHEMBL420648 — IC50 = 4400.0 nM 5.36
CHEMBL323076 — IC50 = 5000.0 nM 5.30
CHEMBL99912 — IC50 = 5000.0 nM 5.30
CHEMBL100055 — IC50 = 5200.0 nM 5.28
CHEMBL328619 — IC50 = 6300.0 nM 5.20
CHEMBL322899 — IC50 = 7000.0 nM 5.16
CHEMBL318731 — IC50 = 7200.0 nM 5.14
CHEMBL103509 — IC50 = 7400.0 nM 5.13
CHEMBL410117 — IC50 = 8000.0 nM 5.10
CHEMBL101705 — IC50 = 9300.0 nM 5.03
CHEMBL414226 — IC50 = 10600.0 nM 4.97
CHEMBL322242 — IC50 = 11000.0 nM 4.96
CHEMBL100060 — IC50 = 11000.0 nM 4.96
CHEMBL99740 — IC50 = 12000.0 nM 4.92
CHEMBL102109 — IC50 = 12000.0 nM 4.92
CHEMBL431059 — IC50 = 12800.0 nM 4.89
CHEMBL321714 — IC50 = 13000.0 nM 4.89
CHEMBL319029 — IC50 = 19000.0 nM 4.72
CHEMBL100668 — IC50 = 21000.0 nM 4.68
CHEMBL100593 — IC50 = 21000.0 nM 4.68
CHEMBL100581 — IC50 = 24000.0 nM 4.62
CHEMBL419345 — IC50 = 28000.0 nM 4.55
CHEMBL99840 — IC50 = 32000.0 nM 4.50
CHEMBL100058 — IC50 > 100000.0 nM -
CHEMBL100527 — IC50 > 100000.0 nM -