Assay Detail
Functional
CHEMBL713367
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of MDA-MB468 tumor cell proliferation
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MDA-MB-468 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Oxindole-based inhibitors of cyclin-dependent kinase 2 (CDK2): design, synthesis, enzymatic activities, and X-ray crystallographic analysis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 5.69 | 6.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL271136 | — | — | 1 | 6.77 |
| CHEMBL409892 | GW305178X | — | 1 | 6.09 |
| CHEMBL1964244 | — | — | 1 | 5.85 |
| CHEMBL1964245 | — | — | 1 | 5.75 |
| CHEMBL269883 | GW416981X | — | 1 | 5.70 |
| CHEMBL1964242 | — | — | 1 | 5.66 |
| CHEMBL1964250 | — | — | 1 | 5.62 |
| CHEMBL411426 | — | — | 1 | 5.36 |
| CHEMBL1964260 | — | — | 1 | 5.35 |
| CHEMBL391229 | — | — | 1 | 5.22 |
| CHEMBL1276446 | — | — | 1 | 5.17 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL271136 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL409892 | GW305178X | IC50 | = | 810.0 | nM | 6.09 |
| CHEMBL1964244 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL1964245 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL269883 | GW416981X | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL1964242 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL1964250 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL411426 | — | IC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL1964260 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL391229 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL1276446 | — | IC50 | = | 6800.0 | nM | 5.17 |