Assay Detail
Binding
CHEMBL713447
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In vitro inhibitory activity against matrilysin (matrix metalloprotease-7).
31
Total Activities
31
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Design, synthesis, and biological evaluation of potent thiazine- and thiazepine-based matrix metalloproteinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 31 | 6.75 | 7.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL140569 | — | — | 1 | 7.80 |
| CHEMBL140511 | — | — | 1 | 7.77 |
| CHEMBL140152 | — | — | 1 | 7.75 |
| CHEMBL141080 | — | — | 1 | 7.64 |
| CHEMBL436205 | — | — | 1 | 7.57 |
| CHEMBL441662 | — | — | 1 | 7.52 |
| CHEMBL140970 | — | — | 1 | 7.52 |
| CHEMBL337594 | — | — | 1 | 7.42 |
| CHEMBL342210 | — | — | 1 | 7.39 |
| CHEMBL2111965 | — | — | 1 | 7.27 |
| CHEMBL334909 | — | — | 1 | 7.10 |
| CHEMBL75094 | PRINOMASTAT | 3.0 | 1 | 7.04 |
| CHEMBL140004 | — | — | 1 | 6.98 |
| CHEMBL514138 | CGS-27023A | — | 1 | 6.97 |
| CHEMBL2112796 | — | — | 1 | 6.96 |
| CHEMBL344633 | — | — | 1 | 6.77 |
| CHEMBL421932 | — | — | 1 | 6.74 |
| CHEMBL140575 | — | — | 1 | 6.50 |
| CHEMBL343082 | — | — | 1 | 6.48 |
| CHEMBL139886 | — | — | 1 | 6.45 |
| CHEMBL344828 | — | — | 1 | 6.29 |
| CHEMBL140720 | — | — | 1 | 6.20 |
| CHEMBL140788 | — | — | 1 | 6.05 |
| CHEMBL140568 | — | — | 1 | 5.96 |
| CHEMBL345054 | — | — | 1 | 5.68 |
| CHEMBL124680 | — | — | 1 | 5.62 |
| CHEMBL344453 | — | — | 1 | 4.89 |
| CHEMBL141451 | — | — | 1 | 4.75 |
| CHEMBL344634 | — | — | 1 | - |
| CHEMBL342172 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL140569 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL140511 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL140152 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL141080 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL436205 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL441662 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL140970 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL337594 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL342210 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL2111965 | — | IC50 | = | 54.0 | nM | 7.27 |
| CHEMBL334909 | — | IC50 | = | 79.0 | nM | 7.10 |
| CHEMBL75094 | PRINOMASTAT | IC50 | = | 91.0 | nM | 7.04 |
| CHEMBL140004 | — | IC50 | = | 105.0 | nM | 6.98 |
| CHEMBL514138 | CGS-27023A | IC50 | = | 106.0 | nM | 6.97 |
| CHEMBL2112796 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL344633 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL421932 | — | IC50 | = | 183.0 | nM | 6.74 |
| CHEMBL140575 | — | IC50 | = | 313.0 | nM | 6.50 |
| CHEMBL343082 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL139886 | — | IC50 | = | 354.0 | nM | 6.45 |
| CHEMBL344828 | — | IC50 | = | 509.0 | nM | 6.29 |
| CHEMBL140720 | — | IC50 | = | 637.0 | nM | 6.20 |
| CHEMBL140788 | — | IC50 | = | 895.0 | nM | 6.05 |
| CHEMBL140568 | — | IC50 | = | 1102.0 | nM | 5.96 |
| CHEMBL345054 | — | IC50 | = | 2070.0 | nM | 5.68 |
| CHEMBL124680 | — | IC50 | = | 2390.0 | nM | 5.62 |
| CHEMBL344453 | — | IC50 | = | 12848.0 | nM | 4.89 |
| CHEMBL141451 | — | IC50 | = | 17651.0 | nM | 4.75 |
| CHEMBL344634 | — | IC50 | < | 100.0 | nM | - |
| CHEMBL342172 | — | IC50 | < | 100.0 | nM | - |
| CHEMBL1234370 | — | IC50 | > | 10000.0 | nM | - |