Assay Detail
Binding
CHEMBL713449
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In vitro inhibitory activity against matrix metalloprotease-7 (MMP-7)
38
Total Activities
38
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Design and synthesis of piperazine-based matrix metalloproteinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 38 | 5.79 | 6.63 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL332134 | — | — | 1 | 6.63 |
| CHEMBL126388 | — | — | 1 | 6.40 |
| CHEMBL127093 | — | — | 1 | 6.38 |
| CHEMBL333586 | — | — | 1 | 6.32 |
| CHEMBL123967 | — | — | 1 | 6.32 |
| CHEMBL338007 | — | — | 1 | 6.30 |
| CHEMBL124100 | — | — | 1 | 6.30 |
| CHEMBL125068 | — | — | 1 | 6.27 |
| CHEMBL123627 | — | — | 1 | 6.19 |
| CHEMBL331095 | — | — | 1 | 6.15 |
| CHEMBL123615 | — | — | 1 | 6.10 |
| CHEMBL332302 | — | — | 1 | 6.09 |
| CHEMBL125755 | — | — | 1 | 6.08 |
| CHEMBL338077 | — | — | 1 | 6.04 |
| CHEMBL125598 | — | — | 1 | 6.03 |
| CHEMBL123563 | — | — | 1 | 5.99 |
| CHEMBL419430 | — | — | 1 | 5.96 |
| CHEMBL125601 | — | — | 1 | 5.95 |
| CHEMBL124514 | — | — | 1 | 5.92 |
| CHEMBL126044 | — | — | 1 | 5.89 |
| CHEMBL339903 | — | — | 1 | 5.84 |
| CHEMBL421644 | — | — | 1 | 5.82 |
| CHEMBL123320 | — | — | 1 | 5.77 |
| CHEMBL124558 | — | — | 1 | 5.72 |
| CHEMBL125672 | — | — | 1 | 5.68 |
| CHEMBL340923 | — | — | 1 | 5.66 |
| CHEMBL124680 | — | — | 1 | 5.62 |
| CHEMBL338223 | — | — | 1 | 5.57 |
| CHEMBL339219 | — | — | 1 | 5.57 |
| CHEMBL123499 | — | — | 1 | 5.49 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL332134 | — | IC50 | = | 232.0 | nM | 6.63 |
| CHEMBL126388 | — | IC50 | = | 401.0 | nM | 6.40 |
| CHEMBL127093 | — | IC50 | = | 416.0 | nM | 6.38 |
| CHEMBL333586 | — | IC50 | = | 483.0 | nM | 6.32 |
| CHEMBL123967 | — | IC50 | = | 483.0 | nM | 6.32 |
| CHEMBL338007 | — | IC50 | = | 502.0 | nM | 6.30 |
| CHEMBL124100 | — | IC50 | = | 497.0 | nM | 6.30 |
| CHEMBL125068 | — | IC50 | = | 537.0 | nM | 6.27 |
| CHEMBL123627 | — | IC50 | = | 642.0 | nM | 6.19 |
| CHEMBL331095 | — | IC50 | = | 710.0 | nM | 6.15 |
| CHEMBL123615 | — | IC50 | = | 787.0 | nM | 6.10 |
| CHEMBL332302 | — | IC50 | = | 821.0 | nM | 6.09 |
| CHEMBL125755 | — | IC50 | = | 824.0 | nM | 6.08 |
| CHEMBL338077 | — | IC50 | = | 908.0 | nM | 6.04 |
| CHEMBL125598 | — | IC50 | = | 931.0 | nM | 6.03 |
| CHEMBL123563 | — | IC50 | = | 1018.0 | nM | 5.99 |
| CHEMBL419430 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL125601 | — | IC50 | = | 1134.0 | nM | 5.95 |
| CHEMBL124514 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL126044 | — | IC50 | = | 1283.0 | nM | 5.89 |
| CHEMBL339903 | — | IC50 | = | 1460.0 | nM | 5.84 |
| CHEMBL421644 | — | IC50 | = | 1522.0 | nM | 5.82 |
| CHEMBL123320 | — | IC50 | = | 1695.0 | nM | 5.77 |
| CHEMBL124558 | — | IC50 | = | 1890.0 | nM | 5.72 |
| CHEMBL125672 | — | IC50 | = | 2093.0 | nM | 5.68 |
| CHEMBL340923 | — | IC50 | = | 2173.0 | nM | 5.66 |
| CHEMBL124680 | — | IC50 | = | 2390.0 | nM | 5.62 |
| CHEMBL338223 | — | IC50 | = | 2690.0 | nM | 5.57 |
| CHEMBL339219 | — | IC50 | = | 2694.0 | nM | 5.57 |
| CHEMBL123499 | — | IC50 | = | 3245.0 | nM | 5.49 |
| CHEMBL435206 | — | IC50 | = | 3290.0 | nM | 5.48 |
| CHEMBL125384 | — | IC50 | = | 4350.0 | nM | 5.36 |
| CHEMBL338453 | — | IC50 | = | 6086.0 | nM | 5.22 |
| CHEMBL124681 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL124026 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL124265 | — | IC50 | = | 15740.0 | nM | 4.80 |
| CHEMBL419607 | — | IC50 | = | 22050.0 | nM | 4.66 |
| CHEMBL125281 | — | IC50 | = | 27680.0 | nM | 4.56 |