Assay Detail
Functional
CHEMBL713480
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro antitumor activity against melanoma M14 tumor cell lines
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | M14 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Structures and cytotoxic properties of trichoverroids and their macrolide analogues produced by saltwater culture of Myrothecium verrucaria.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 6.59 | 8.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL136396 | VERRUCARRIN M | — | 1 | 8.10 |
| CHEMBL341800 | (6'R,13'S) ISORORIDIN A | — | 1 | 8.00 |
| CHEMBL136268 | RORIDIN L | — | 1 | 7.62 |
| CHEMBL435984 | RORIDIN M | — | 1 | 7.12 |
| CHEMBL136186 | TRICHOVERRIN B | — | 1 | 5.15 |
| CHEMBL136053 | TRICHOVERRIN A | — | 1 | 5.10 |
| CHEMBL335603 | 13`-ACETYLTRICHOVERRIN B | — | 1 | 5.05 |
| CHEMBL335838 | — | — | 1 | - |
| CHEMBL433680 | ANGUIDIN | — | 1 | - |
| CHEMBL334648 | RORIDIN A | — | 1 | - |
| CHEMBL2368056 | Miophytocen C | — | 1 | - |
| CHEMBL136985 | VERRUCARIN A | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL136396 | VERRUCARRIN M | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL341800 | (6'R,13'S) ISORORIDIN A | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL136268 | RORIDIN L | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL435984 | RORIDIN M | IC50 | = | 75.0 | nM | 7.12 |
| CHEMBL136186 | TRICHOVERRIN B | IC50 | = | 7100.0 | nM | 5.15 |
| CHEMBL136053 | TRICHOVERRIN A | IC50 | = | 7870.0 | nM | 5.10 |
| CHEMBL335603 | 13`-ACETYLTRICHOVERRIN B | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL335838 | — | IC50 | < | 1.0 | nM | - |
| CHEMBL433680 | ANGUIDIN | IC50 | < | 1.0 | nM | - |
| CHEMBL334648 | RORIDIN A | IC50 | < | 1.0 | nM | - |
| CHEMBL2368056 | Miophytocen C | IC50 | > | 10000.0 | nM | - |
| CHEMBL136985 | VERRUCARIN A | IC50 | < | 1.0 | nM | - |