Assay Detail
Functional
CHEMBL713650
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Metabotropic glutamate receptor 6 agonist activity to influence forskolin stimulated c-AMP formation in rat non neuronal cells
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Cell Type | neuronal |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Target
Metabotropic glutamate receptor 6 (CHEMBL3842) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
(2S,1'S,2'R,3'R)-2-(2'-Carboxy-3'-hydroxymethylcyclopropyl) glycine is a highly potent group 2 and 3 metabotropic glutamate receptor agonist with oral activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 6 | 6.17 | 7.26 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL33567 | — | — | 1 | 7.26 |
| CHEMBL140197 | — | — | 1 | 6.83 |
| CHEMBL280563 | — | — | 1 | 6.22 |
| CHEMBL334160 | — | — | 1 | 5.92 |
| CHEMBL143210 | — | — | 1 | 5.44 |
| CHEMBL277475 | — | — | 1 | 5.33 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL33567 | — | EC50 | = | 55.0 | nM | 7.26 |
| CHEMBL140197 | — | EC50 | = | 147.0 | nM | 6.83 |
| CHEMBL280563 | — | EC50 | = | 600.0 | nM | 6.22 |
| CHEMBL334160 | — | EC50 | = | 1198.0 | nM | 5.92 |
| CHEMBL143210 | — | EC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL277475 | — | EC50 | = | 4700.0 | nM | 5.33 |