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Assay Detail

CHEMBL713745

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Inhibitory activity against MCF-10A human breast cell line
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type MCF-10A
Confidence 1 — Organism
Curated By Intermediate

Target

MCF-10A (CHEMBL614321)
Type CELL-LINE
Organism Homo sapiens

Publication

Design, synthesis, and evaluation of novel boronic-chalcone derivatives as antitumor agents.
Kumar SK, Hager E, Pettit C, Gurulingappa H, Davidson NE, Khan SR.
J Med Chem (2003) 46 : 2813 -2815
PubMed 12825923 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 13 4.60 4.92

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL96817 1 4.92
CHEMBL95090 1 4.89
CHEMBL319204 1 4.82
CHEMBL93446 1 4.77
CHEMBL440145 1 4.75
CHEMBL93371 1 4.75
CHEMBL96702 1 4.75
CHEMBL96269 1 4.60
CHEMBL94639 1 4.42
CHEMBL96581 1 4.42
CHEMBL328253 1 4.36
CHEMBL94637 1 4.20
CHEMBL94710 1 4.12

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL96817 IC50 = 12000.0 nM 4.92
CHEMBL95090 IC50 = 13000.0 nM 4.89
CHEMBL319204 IC50 = 15000.0 nM 4.82
CHEMBL93446 IC50 = 17000.0 nM 4.77
CHEMBL440145 IC50 = 18000.0 nM 4.75
CHEMBL93371 IC50 = 18000.0 nM 4.75
CHEMBL96702 IC50 = 18000.0 nM 4.75
CHEMBL96269 IC50 = 25000.0 nM 4.60
CHEMBL94639 IC50 = 38000.0 nM 4.42
CHEMBL96581 IC50 = 38000.0 nM 4.42
CHEMBL328253 IC50 = 44000.0 nM 4.36
CHEMBL94637 IC50 = 63000.0 nM 4.20
CHEMBL94710 IC50 = 75000.0 nM 4.12