Assay Detail
Functional
CHEMBL713827
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Compound was evaluated for inhibition of tumor cell growth in Manca human lymphoma cell line
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Manca |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Folate analogues. 35. Synthesis and biological evaluation of 1-deaza, 3-deaza, and bridge-elongated analogues of N10-propargyl-5,8-dideazafolic acid.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.40 | 7.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL25889 | — | — | 1 | 7.89 |
| CHEMBL422395 | — | — | 1 | 6.25 |
| CHEMBL92234 | — | — | 1 | 5.05 |
| CHEMBL329619 | — | — | 1 | - |
| CHEMBL419876 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL25889 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL422395 | — | IC50 | = | 560.0 | nM | 6.25 |
| CHEMBL92234 | — | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL329619 | — | IC50 | > | 80000.0 | nM | - |
| CHEMBL419876 | — | IC50 | > | 600000.0 | nM | - |