Assay Detail
Binding
CHEMBL713834
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Inhibitory activity against Matrix metalloprotease-8
64
Total Activities
64
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Carbonic anhydrase and matrix metalloproteinase inhibitors: sulfonylated amino acid hydroxamates with MMP inhibitory properties act as efficient inhibitors of CA isozymes I, II, and IV, and N-hydroxysulfonamides inhibit both these zinc enzymes.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 64 | 6.84 | 10.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL293503 | — | — | 1 | 10.00 |
| CHEMBL123775 | — | — | 1 | 9.52 |
| CHEMBL340461 | — | — | 1 | 9.22 |
| CHEMBL122711 | — | — | 1 | 9.00 |
| CHEMBL332755 | — | — | 1 | 9.00 |
| CHEMBL123463 | — | — | 1 | 8.96 |
| CHEMBL306726 | — | — | 1 | 8.96 |
| CHEMBL262676 | — | — | 1 | 8.96 |
| CHEMBL432223 | — | — | 1 | 8.89 |
| CHEMBL122836 | — | — | 1 | 8.64 |
| CHEMBL55110 | — | — | 1 | 8.62 |
| CHEMBL331311 | — | — | 1 | 8.48 |
| CHEMBL330857 | — | — | 1 | 8.38 |
| CHEMBL123041 | — | — | 1 | 8.31 |
| CHEMBL304281 | — | — | 1 | 8.29 |
| CHEMBL441084 | — | — | 1 | 8.28 |
| CHEMBL122719 | — | — | 1 | 8.26 |
| CHEMBL122831 | — | — | 1 | 8.19 |
| CHEMBL331342 | — | — | 1 | 8.05 |
| CHEMBL311336 | — | — | 1 | 7.89 |
| CHEMBL332120 | — | — | 1 | 7.75 |
| CHEMBL316169 | — | — | 1 | 7.72 |
| CHEMBL450327 | — | — | 1 | 7.70 |
| CHEMBL293774 | — | — | 1 | 7.68 |
| CHEMBL122651 | — | — | 1 | 7.57 |
| CHEMBL440714 | — | — | 1 | 7.57 |
| CHEMBL82868 | — | — | 1 | 7.51 |
| CHEMBL120049 | — | — | 1 | 7.00 |
| CHEMBL332406 | — | — | 1 | 6.98 |
| CHEMBL123443 | — | — | 1 | 6.97 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL293503 | — | Ki | = | 0.1 | nM | 10.00 |
| CHEMBL123775 | — | Ki | = | 0.3 | nM | 9.52 |
| CHEMBL340461 | — | Ki | = | 0.6 | nM | 9.22 |
| CHEMBL122711 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL332755 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL123463 | — | Ki | = | 1.1 | nM | 8.96 |
| CHEMBL306726 | — | Ki | = | 1.1 | nM | 8.96 |
| CHEMBL262676 | — | Ki | = | 1.1 | nM | 8.96 |
| CHEMBL432223 | — | Ki | = | 1.3 | nM | 8.89 |
| CHEMBL122836 | — | Ki | = | 2.3 | nM | 8.64 |
| CHEMBL55110 | — | Ki | = | 2.4 | nM | 8.62 |
| CHEMBL331311 | — | Ki | = | 3.3 | nM | 8.48 |
| CHEMBL330857 | — | Ki | = | 4.2 | nM | 8.38 |
| CHEMBL123041 | — | Ki | = | 4.9 | nM | 8.31 |
| CHEMBL304281 | — | Ki | = | 5.1 | nM | 8.29 |
| CHEMBL441084 | — | Ki | = | 5.3 | nM | 8.28 |
| CHEMBL122719 | — | Ki | = | 5.5 | nM | 8.26 |
| CHEMBL122831 | — | Ki | = | 6.4 | nM | 8.19 |
| CHEMBL331342 | — | Ki | = | 9.0 | nM | 8.05 |
| CHEMBL311336 | — | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL332120 | — | Ki | = | 18.0 | nM | 7.75 |
| CHEMBL316169 | — | Ki | = | 19.0 | nM | 7.72 |
| CHEMBL450327 | — | Ki | = | 20.0 | nM | 7.70 |
| CHEMBL293774 | — | Ki | = | 21.0 | nM | 7.68 |
| CHEMBL440714 | — | Ki | = | 27.0 | nM | 7.57 |
| CHEMBL122651 | — | Ki | = | 27.0 | nM | 7.57 |
| CHEMBL82868 | — | Ki | = | 31.0 | nM | 7.51 |
| CHEMBL120049 | — | Ki | = | 101.0 | nM | 7.00 |
| CHEMBL332406 | — | Ki | = | 104.0 | nM | 6.98 |
| CHEMBL123443 | — | Ki | = | 108.0 | nM | 6.97 |
| CHEMBL333248 | — | Ki | = | 111.0 | nM | 6.96 |
| CHEMBL331669 | — | Ki | = | 116.0 | nM | 6.94 |
| CHEMBL332429 | — | Ki | = | 118.0 | nM | 6.93 |
| CHEMBL333532 | — | Ki | = | 120.0 | nM | 6.92 |
| CHEMBL123382 | — | Ki | = | 123.0 | nM | 6.91 |
| CHEMBL121916 | — | Ki | = | 126.0 | nM | 6.90 |
| CHEMBL333896 | — | Ki | = | 125.0 | nM | 6.90 |
| CHEMBL123167 | — | Ki | = | 125.0 | nM | 6.90 |
| CHEMBL332858 | — | Ki | = | 130.0 | nM | 6.89 |
| CHEMBL83508 | — | Ki | = | 155.0 | nM | 6.81 |
| CHEMBL122925 | — | Ki | = | 1000.0 | nM | 6.00 |
| CHEMBL332362 | — | Ki | = | 1500.0 | nM | 5.82 |
| CHEMBL122950 | — | Ki | = | 10000.0 | nM | 5.00 |
| CHEMBL123233 | — | Ki | = | 12000.0 | nM | 4.92 |
| CHEMBL121729 | — | Ki | = | 15000.0 | nM | 4.82 |
| CHEMBL121592 | — | Ki | = | 16000.0 | nM | 4.80 |
| CHEMBL331114 | — | Ki | = | 16000.0 | nM | 4.80 |
| CHEMBL122868 | — | Ki | = | 16000.0 | nM | 4.80 |
| CHEMBL123105 | — | Ki | = | 21000.0 | nM | 4.68 |
| CHEMBL122109 | — | Ki | = | 23000.0 | nM | 4.64 |