Assay Detail
Binding
CHEMBL713836
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory activity against matrix metalloprotease-8
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Structure-based design and synthesis of potent matrix metalloproteinase inhibitors derived from a 6H-1,3,4-thiadiazine scaffold.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 20 | 6.57 | 7.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL109861 | — | — | 1 | 7.22 |
| CHEMBL110750 | — | — | 1 | 6.96 |
| CHEMBL109353 | — | — | 1 | 6.82 |
| CHEMBL321213 | — | — | 1 | 6.77 |
| CHEMBL111678 | — | — | 1 | 6.75 |
| CHEMBL419750 | — | — | 1 | 6.75 |
| CHEMBL109579 | — | — | 1 | 6.72 |
| CHEMBL111179 | — | — | 1 | 6.70 |
| CHEMBL110970 | — | — | 1 | 6.68 |
| CHEMBL422250 | — | — | 1 | 6.66 |
| CHEMBL109214 | — | — | 1 | 6.66 |
| CHEMBL111450 | — | — | 1 | 6.64 |
| CHEMBL109770 | — | — | 1 | 6.58 |
| CHEMBL109655 | — | — | 1 | 6.52 |
| CHEMBL322795 | — | — | 1 | 6.46 |
| CHEMBL109806 | — | — | 1 | 6.32 |
| CHEMBL111257 | — | — | 1 | 6.14 |
| CHEMBL109603 | — | — | 1 | 6.11 |
| CHEMBL422251 | — | — | 1 | 5.36 |
| CHEMBL108494 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL109861 | — | Ki | = | 60.0 | nM | 7.22 |
| CHEMBL110750 | — | Ki | = | 110.0 | nM | 6.96 |
| CHEMBL109353 | — | Ki | = | 150.0 | nM | 6.82 |
| CHEMBL321213 | — | Ki | = | 170.0 | nM | 6.77 |
| CHEMBL111678 | — | Ki | = | 180.0 | nM | 6.75 |
| CHEMBL419750 | — | Ki | = | 180.0 | nM | 6.75 |
| CHEMBL109579 | — | Ki | = | 190.0 | nM | 6.72 |
| CHEMBL111179 | — | Ki | = | 200.0 | nM | 6.70 |
| CHEMBL110970 | — | Ki | = | 210.0 | nM | 6.68 |
| CHEMBL422250 | — | Ki | = | 220.0 | nM | 6.66 |
| CHEMBL109214 | — | Ki | = | 220.0 | nM | 6.66 |
| CHEMBL111450 | — | Ki | = | 230.0 | nM | 6.64 |
| CHEMBL109770 | — | Ki | = | 260.0 | nM | 6.58 |
| CHEMBL109655 | — | Ki | = | 300.0 | nM | 6.52 |
| CHEMBL322795 | — | Ki | = | 350.0 | nM | 6.46 |
| CHEMBL109806 | — | Ki | = | 480.0 | nM | 6.32 |
| CHEMBL111257 | — | Ki | = | 730.0 | nM | 6.14 |
| CHEMBL109603 | — | Ki | = | 780.0 | nM | 6.11 |
| CHEMBL422251 | — | Ki | = | 4370.0 | nM | 5.36 |
| CHEMBL108494 | — | Ki | > | 15000.0 | nM | - |