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Assay Detail

CHEMBL713839

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of human Matrix metalloprotease-8
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Expert

Target

Neutrophil collagenase (CHEMBL4588)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Hydroxamate inhibitors of human gelatinase B (92 kDa)
Wahl RC, Pulvino TA, Mathiowetz AM, Ghose AK, Johnson JS, Delecki D, Cook ER, Gainor JA, Gowravaram MR, Tomczuk BE
Bioorg Med Chem Lett (1995) 5 : 349 -352
· DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 11 6.84 8.33

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL325015 1 8.33
CHEMBL324369 1 7.00
CHEMBL117296 1 6.77
CHEMBL117720 1 6.72
CHEMBL332891 1 5.38
CHEMBL87229 1 -
CHEMBL11306 1 -
CHEMBL410259 1 -
CHEMBL116318 1 -
CHEMBL19611 ILOMASTAT 2.0 1 -
CHEMBL59023 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL325015 Ki = 4.7 nM 8.33
CHEMBL324369 Ki = 100.0 nM 7.00
CHEMBL117296 Ki = 170.0 nM 6.77
CHEMBL117720 Ki = 190.0 nM 6.72
CHEMBL332891 Ki = 4200.0 nM 5.38
CHEMBL87229 Ki < 2.0 nM -
CHEMBL11306 Ki < 1.0 nM -
CHEMBL410259 Ki < 2.0 nM -
CHEMBL116318 Ki < 2.0 nM -
CHEMBL19611 ILOMASTAT Ki < 1.0 nM -
CHEMBL59023 Ki < 2.0 nM -