Assay Detail
Binding
CHEMBL713848
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Matrix metalloprotease-8 (MMP-8) in fluorimetric assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Phenoxyphenyl sulfone N-formylhydroxylamines (retrohydroxamates) as potent, selective, orally bioavailable matrix metalloproteinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 8.97 | 9.33 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL279785 | MARIMASTAT | 3.0 | 1 | 9.33 |
| CHEMBL75094 | PRINOMASTAT | 3.0 | 1 | 9.27 |
| CHEMBL2115165 | — | — | 1 | 8.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL279785 | MARIMASTAT | IC50 | = | 0.47 | nM | 9.33 |
| CHEMBL75094 | PRINOMASTAT | IC50 | = | 0.54 | nM | 9.27 |
| CHEMBL2115165 | — | IC50 | = | 5.0 | nM | 8.30 |