Assay Detail
Binding
CHEMBL713851
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Inhibition of Matrix metalloprotease-8 (MMP-8)
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
P1, P2'-linked macrocyclic amine derivatives as matrix metalloproteinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 8.15 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL34085 | — | — | 1 | 8.40 |
| CHEMBL32596 | — | — | 1 | 8.15 |
| CHEMBL32631 | — | — | 1 | 7.89 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL34085 | — | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL32596 | — | Ki | = | 7.0 | nM | 8.15 |
| CHEMBL32631 | — | Ki | = | 13.0 | nM | 7.89 |