Assay Detail

CHEMBL713923

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Functional

In vitro inhibitory concentration of compound against human cancer MEXF 514 cell line was determined

ChEMBL ↗

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Target

MEXF514 (CHEMBL614873) ↗

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Primary target MEXF514

CHEMBL614873

Anchored from Assay target.

Protein identity MEXF514

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Homo sapiens
Cell Type	MEXF514
Confidence	1 — Organism
Curated By	Intermediate

Target

MEXF514 (CHEMBL614873) ↗

Type	CELL-LINE
Organism	Homo sapiens

Publication

Synthesis and in vitro efficacy of acid-sensitive poly(ethylene glycol) paclitaxel conjugates.

Rodrigues P, Scheuermann K, Stockmar C, Maier G, Fiebig H, Unger C, Mulhaupt R, Kratz F.
Bioorg Med Chem Lett (2003) 13 : 355 -360
PubMed 12882225 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	2	6.33	6.66

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL384552	—	—	1	6.66
CHEMBL428647	PACLITAXEL	4.0	1	5.99

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL384552	—	IC50	=	220.0	nM	6.66
CHEMBL428647	PACLITAXEL	IC50	=	1030.0	nM	5.99