Assay Detail
Binding
CHEMBL714049
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Inhibition of MEK1/ERK (MAP Kinase kinase) in cascade assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Soluble 2-substituted aminopyrido[2,3-d]pyrimidin-7-yl ureas. Structure-activity relationships against selected tyrosine kinases and exploration of in vitro and in vivo anticancer activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.34 | 5.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL45827 | — | — | 1 | 5.55 |
| CHEMBL56983 | — | — | 1 | 5.30 |
| CHEMBL57347 | — | — | 1 | 5.16 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL45827 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL56983 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL57347 | — | IC50 | = | 7000.0 | nM | 5.16 |