Assay Detail
Functional
CHEMBL714064
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In vitro antiherpesvirus activity against MRC-5 cells infected with HCMV (AD-169 strain)
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MRC5 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis and antiviral activity of methyl derivatives of 9-[2-(phosphonomethoxy)ethyl]guanine.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.69 | 7.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL223737 | GS-438 | -1.0 | 1 | 7.05 |
| CHEMBL92289 | — | — | 1 | 6.10 |
| CHEMBL19976 | — | — | 1 | 5.89 |
| CHEMBL419692 | — | — | 1 | 5.80 |
| CHEMBL182 | GANCICLOVIR | 4.0 | 1 | 5.40 |
| CHEMBL91794 | — | — | 1 | 4.80 |
| CHEMBL92761 | — | — | 1 | 4.80 |
| CHEMBL99758 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL223737 | GS-438 | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL92289 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL19976 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL419692 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL182 | GANCICLOVIR | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL91794 | — | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL92761 | — | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL99758 | — | IC50 | > | 300000.0 | nM | - |