Assay Detail
Functional
CHEMBL714183
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Inhibition constant against the transport of [3H]- methotrexate (MTX) by MOLT-4 T-cell
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MOLT-4 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Benzoquinazoline inhibitors of thymidylate synthase: enzyme inhibitory activity and cytotoxicity of some sulfonamidobenzoylglutamate and related derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 4.82 | 5.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL117687 | — | — | 1 | 5.75 |
| CHEMBL324739 | — | — | 1 | 5.31 |
| CHEMBL324932 | — | — | 1 | 4.82 |
| CHEMBL333402 | — | — | 1 | 4.52 |
| CHEMBL325972 | — | — | 1 | 4.38 |
| CHEMBL117335 | — | — | 1 | 4.14 |
| CHEMBL117611 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL117687 | — | Ki | = | 1800.0 | nM | 5.75 |
| CHEMBL324739 | — | Ki | = | 4900.0 | nM | 5.31 |
| CHEMBL324932 | — | Ki | = | 15000.0 | nM | 4.82 |
| CHEMBL333402 | — | Ki | = | 30000.0 | nM | 4.52 |
| CHEMBL325972 | — | Ki | = | 42000.0 | nM | 4.38 |
| CHEMBL117335 | — | Ki | = | 72000.0 | nM | 4.14 |
| CHEMBL117611 | — | Ki | = | - | nM | - |