Assay Detail
Functional
CHEMBL714186
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In vitro inhibitory activity against MOLT-4 T-cell leukemia cell AICAR transformylase
5
Total Activities
5
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MOLT-4 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis and biological activity of open-chain analogues of 5,6,7,8-tetrahydrofolic acid--potential antitumor agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 4.35 | 4.59 |
| Inhibition | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL30842 | — | — | 1 | 4.59 |
| CHEMBL31176 | — | — | 1 | 4.10 |
| CHEMBL285232 | — | — | 1 | - |
| CHEMBL417304 | — | — | 1 | - |
| CHEMBL31027 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL30842 | — | IC50 | = | 25800.0 | nM | 4.59 |
| CHEMBL31176 | — | IC50 | = | 79300.0 | nM | 4.10 |
| CHEMBL285232 | — | IC50 | = | 133000.0 | nM | - |
| CHEMBL417304 | — | IC50 | = | 182000.0 | nM | - |
| CHEMBL31027 | — | Inhibition | = | 26.0 | % | - |