Assay Detail
Functional
CHEMBL714190
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Cytotoxic effect on the growth of human T-and B-lymphoblastoid cell lines(MOLT-4 and MGL-8) evaluated by measuring inhibition of thymidine intake in presence of 10 uM deoxyguanosine
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MOLT-4 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Inhibitors of human purine nucleoside phosphorylase. Synthesis and biological activities of 8-amino-3-benzylhypoxanthine and related analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 5.05 | 6.11 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL8230 | — | — | 1 | 6.11 |
| CHEMBL285627 | — | — | 1 | 6.09 |
| CHEMBL33189 | — | — | 1 | 5.83 |
| CHEMBL2021376 | — | — | 1 | 5.49 |
| CHEMBL285258 | — | — | 1 | 4.92 |
| CHEMBL35812 | — | — | 1 | 4.54 |
| CHEMBL33826 | — | — | 1 | 4.54 |
| CHEMBL33416 | — | — | 1 | 4.46 |
| CHEMBL32496 | — | — | 1 | 4.37 |
| CHEMBL35668 | — | — | 1 | 4.19 |
| CHEMBL415041 | — | — | 1 | - |
| CHEMBL284608 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL8230 | — | IC50 | = | 770.0 | nM | 6.11 |
| CHEMBL285627 | — | IC50 | = | 820.0 | nM | 6.09 |
| CHEMBL33189 | — | IC50 | = | 1470.0 | nM | 5.83 |
| CHEMBL2021376 | — | IC50 | = | 3250.0 | nM | 5.49 |
| CHEMBL285258 | — | IC50 | = | 11900.0 | nM | 4.92 |
| CHEMBL35812 | — | IC50 | = | 29100.0 | nM | 4.54 |
| CHEMBL33826 | — | IC50 | = | 28600.0 | nM | 4.54 |
| CHEMBL33416 | — | IC50 | = | 35000.0 | nM | 4.46 |
| CHEMBL32496 | — | IC50 | = | 42500.0 | nM | 4.37 |
| CHEMBL35668 | — | IC50 | = | 65200.0 | nM | 4.19 |
| CHEMBL415041 | — | IC50 | = | 204200.0 | nM | - |
| CHEMBL284608 | — | IC50 | > | 25000.0 | nM | - |