Assay Detail
Binding
CHEMBL714222
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Inhibitory activity against matrix metalloprotease-2 (MMP-2)
33
Total Activities
33
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Rational design, synthesis and structure-activity relationships of a cyclic succinate series of TNF-alpha converting enzyme inhibitors. Part 2: lead optimization.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 33 | 6.08 | 6.32 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL137323 | — | — | 1 | 6.32 |
| CHEMBL137365 | — | — | 1 | 6.19 |
| CHEMBL423906 | — | — | 1 | 6.18 |
| CHEMBL137383 | — | — | 1 | 6.11 |
| CHEMBL137065 | — | — | 1 | 6.00 |
| CHEMBL137732 | — | — | 1 | 5.95 |
| CHEMBL422821 | — | — | 1 | 5.81 |
| CHEMBL336832 | — | — | 1 | - |
| CHEMBL137297 | — | — | 1 | - |
| CHEMBL341380 | — | — | 1 | - |
| CHEMBL137703 | — | — | 1 | - |
| CHEMBL134908 | — | — | 1 | - |
| CHEMBL137315 | — | — | 1 | - |
| CHEMBL133028 | — | — | 1 | - |
| CHEMBL134782 | — | — | 1 | - |
| CHEMBL133259 | — | — | 1 | - |
| CHEMBL134640 | — | — | 1 | - |
| CHEMBL135766 | — | — | 1 | - |
| CHEMBL342870 | — | — | 1 | - |
| CHEMBL341817 | — | — | 1 | - |
| CHEMBL342687 | — | — | 1 | - |
| CHEMBL135499 | — | — | 1 | - |
| CHEMBL337849 | — | — | 1 | - |
| CHEMBL435399 | — | — | 1 | - |
| CHEMBL137646 | — | — | 1 | - |
| CHEMBL137013 | — | — | 1 | - |
| CHEMBL132928 | — | — | 1 | - |
| CHEMBL343548 | — | — | 1 | - |
| CHEMBL135696 | — | — | 1 | - |
| CHEMBL339380 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL137323 | — | Ki | = | 476.0 | nM | 6.32 |
| CHEMBL137365 | — | Ki | = | 642.0 | nM | 6.19 |
| CHEMBL423906 | — | Ki | = | 656.0 | nM | 6.18 |
| CHEMBL137383 | — | Ki | = | 771.0 | nM | 6.11 |
| CHEMBL137065 | — | Ki | = | 1002.0 | nM | 6.00 |
| CHEMBL137732 | — | Ki | = | 1111.0 | nM | 5.95 |
| CHEMBL422821 | — | Ki | = | 1537.0 | nM | 5.81 |
| CHEMBL341380 | — | Ki | > | 3333.0 | nM | - |
| CHEMBL136353 | — | Ki | > | 3333.0 | nM | - |
| CHEMBL137703 | — | Ki | > | 3333.0 | nM | - |
| CHEMBL134908 | — | Ki | > | 3333.0 | nM | - |
| CHEMBL137315 | — | Ki | > | 3333.0 | nM | - |
| CHEMBL133028 | — | Ki | > | 3333.0 | nM | - |
| CHEMBL134782 | — | Ki | > | 3333.0 | nM | - |
| CHEMBL133259 | — | Ki | > | 3333.0 | nM | - |
| CHEMBL134640 | — | Ki | > | 3333.0 | nM | - |
| CHEMBL135766 | — | Ki | > | 3333.0 | nM | - |
| CHEMBL137297 | — | Ki | > | 3333.0 | nM | - |
| CHEMBL138594 | — | Ki | > | 3333.0 | nM | - |
| CHEMBL344843 | — | Ki | > | 3333.0 | nM | - |
| CHEMBL336832 | — | Ki | > | 3333.0 | nM | - |
| CHEMBL342870 | — | Ki | > | 2454.0 | nM | - |
| CHEMBL341817 | — | Ki | > | 3333.0 | nM | - |
| CHEMBL342687 | — | Ki | > | 3333.0 | nM | - |
| CHEMBL135499 | — | Ki | > | 3333.0 | nM | - |
| CHEMBL337849 | — | Ki | > | 3333.0 | nM | - |
| CHEMBL435399 | — | Ki | > | 3333.0 | nM | - |
| CHEMBL137646 | — | Ki | > | 3333.0 | nM | - |
| CHEMBL137013 | — | Ki | > | 3333.0 | nM | - |
| CHEMBL132928 | — | Ki | > | 3333.0 | nM | - |
| CHEMBL343548 | — | Ki | > | 1011.0 | nM | - |
| CHEMBL135696 | — | Ki | > | 3333.0 | nM | - |
| CHEMBL339380 | — | Ki | > | 3333.0 | nM | - |