Assay Detail
Binding
CHEMBL714224
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Inhibition of Matrix metalloprotease-2
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Macrocyclic amino carboxylates as selective MMP-8 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 5.95 | 6.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL298167 | — | — | 1 | 6.62 |
| CHEMBL48256 | — | — | 1 | 6.60 |
| CHEMBL48786 | — | — | 1 | 5.81 |
| CHEMBL46183 | — | — | 1 | 5.62 |
| CHEMBL50228 | — | — | 1 | 5.09 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL298167 | — | Ki | = | 238.0 | nM | 6.62 |
| CHEMBL48256 | — | Ki | = | 249.0 | nM | 6.60 |
| CHEMBL48786 | — | Ki | = | 1533.0 | nM | 5.81 |
| CHEMBL46183 | — | Ki | = | 2400.0 | nM | 5.62 |
| CHEMBL50228 | — | Ki | = | 8100.0 | nM | 5.09 |