Assay Detail
Functional
CHEMBL714272
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Compound was evaluated for inhibition of MTX influx into MOLT-4 cells
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MOLT-4 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Folate analogues. 35. Synthesis and biological evaluation of 1-deaza, 3-deaza, and bridge-elongated analogues of N10-propargyl-5,8-dideazafolic acid.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 5.22 | 5.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL34259 | METHOTREXATE | 4.0 | 1 | 5.85 |
| CHEMBL25889 | — | — | 1 | 5.82 |
| CHEMBL224622 | — | — | 1 | 5.46 |
| CHEMBL92234 | — | — | 1 | 5.35 |
| CHEMBL90795 | — | — | 1 | 5.35 |
| CHEMBL92589 | — | — | 1 | 5.16 |
| CHEMBL422395 | — | — | 1 | 4.55 |
| CHEMBL329619 | — | — | 1 | 4.24 |
| CHEMBL1622 | FOLIC ACID | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL34259 | METHOTREXATE | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL25889 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL224622 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL92234 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL90795 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL92589 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL422395 | — | IC50 | = | 28000.0 | nM | 4.55 |
| CHEMBL329619 | — | IC50 | = | 58000.0 | nM | 4.24 |
| CHEMBL1622 | FOLIC ACID | IC50 | > | 100000.0 | nM | - |