Assay Detail
Functional
CHEMBL714274
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antitumor activity against human acute T-lymphoblastic leukemia MOLT-4 cells
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MOLT-4 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Antitumor agents. 1. Synthesis, biological evaluation, and molecular modeling of 5H-pyrido[3,2-a]phenoxazin-5-one, a compound with potent antiproliferative activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 7.74 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1554 | DACTINOMYCIN | 4.0 | 1 | 9.00 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 7.70 |
| CHEMBL151423 | — | — | 1 | 7.40 |
| CHEMBL348434 | — | — | 1 | 6.85 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1554 | DACTINOMYCIN | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL151423 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL348434 | — | IC50 | = | 140.0 | nM | 6.85 |