Assay Detail
Functional
CHEMBL714309
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Growth inhibitory activity against murine Lewis lung carcinoma cell line
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | Lewis lung carcinoma |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis and cytotoxic activity of carboxamide derivatives of benzo[b][1,6]naphthyridines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 7.65 | 8.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL9676 | — | — | 1 | 8.77 |
| CHEMBL9595 | — | — | 1 | 8.43 |
| CHEMBL268798 | — | — | 1 | 8.36 |
| CHEMBL9902 | — | — | 1 | 8.33 |
| CHEMBL269663 | — | — | 1 | 8.00 |
| CHEMBL9489 | — | — | 1 | 7.82 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 7.66 |
| CHEMBL65 | CAMPTOTHECIN | -1.0 | 1 | 7.48 |
| CHEMBL266809 | — | — | 1 | 7.30 |
| CHEMBL276261 | — | — | 1 | 7.00 |
| CHEMBL611408 | — | — | 1 | 6.79 |
| CHEMBL44657 | ETOPOSIDE | 4.0 | 1 | 6.75 |
| CHEMBL9940 | — | — | 1 | 6.72 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL9676 | — | IC50 | = | 1.7 | nM | 8.77 |
| CHEMBL9595 | — | IC50 | = | 3.7 | nM | 8.43 |
| CHEMBL268798 | — | IC50 | = | 4.4 | nM | 8.36 |
| CHEMBL9902 | — | IC50 | = | 4.7 | nM | 8.33 |
| CHEMBL269663 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL9489 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL65 | CAMPTOTHECIN | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL266809 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL276261 | — | IC50 | = | 101.0 | nM | 7.00 |
| CHEMBL611408 | — | IC50 | = | 161.0 | nM | 6.79 |
| CHEMBL44657 | ETOPOSIDE | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL9940 | — | IC50 | = | 190.0 | nM | 6.72 |