Assay Detail
Binding
CHEMBL714370
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In vitro activation of mouse recombinant Melanocortin-4 receptor.
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Structure-activity relationships of the melanocortin tetrapeptide Ac-His-DPhe-Arg-Trp-NH(2) at the mouse melanocortin receptors. 1. Modifications at the His position.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 21 | 6.69 | 10.06 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL386583 | — | — | 1 | 10.06 |
| CHEMBL441738 | AFAMELANOTIDE | 4.0 | 1 | 9.68 |
| CHEMBL214332 | INTERMEDINE | 2.0 | 1 | 8.27 |
| CHEMBL264190 | — | — | 1 | 7.76 |
| CHEMBL405174 | — | — | 1 | 7.68 |
| CHEMBL327479 | — | — | 1 | 7.15 |
| CHEMBL330561 | — | — | 1 | 7.04 |
| CHEMBL317968 | — | — | 1 | 6.89 |
| CHEMBL431092 | — | — | 1 | 6.68 |
| CHEMBL94391 | — | — | 1 | 6.30 |
| CHEMBL432201 | — | — | 1 | 6.28 |
| CHEMBL96531 | — | — | 1 | 6.15 |
| CHEMBL317969 | — | — | 1 | 6.05 |
| CHEMBL330233 | — | — | 1 | 6.00 |
| CHEMBL320157 | — | — | 1 | 5.82 |
| CHEMBL329490 | — | — | 1 | 5.82 |
| CHEMBL329847 | — | — | 1 | 5.66 |
| CHEMBL96871 | — | — | 1 | 5.54 |
| CHEMBL94369 | — | — | 1 | 5.54 |
| CHEMBL432027 | — | — | 1 | 5.21 |
| CHEMBL275303 | — | — | 1 | 4.93 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL386583 | — | EC50 | = | 0.087 | nM | 10.06 |
| CHEMBL441738 | AFAMELANOTIDE | EC50 | = | 0.21 | nM | 9.68 |
| CHEMBL214332 | INTERMEDINE | EC50 | = | 5.37 | nM | 8.27 |
| CHEMBL264190 | — | EC50 | = | 17.2 | nM | 7.76 |
| CHEMBL405174 | — | EC50 | = | 21.1 | nM | 7.68 |
| CHEMBL327479 | — | EC50 | = | 70.6 | nM | 7.15 |
| CHEMBL330561 | — | EC50 | = | 91.2 | nM | 7.04 |
| CHEMBL317968 | — | EC50 | = | 128.0 | nM | 6.89 |
| CHEMBL431092 | — | EC50 | = | 211.0 | nM | 6.68 |
| CHEMBL94391 | — | EC50 | = | 506.0 | nM | 6.30 |
| CHEMBL432201 | — | EC50 | = | 528.0 | nM | 6.28 |
| CHEMBL96531 | — | EC50 | = | 714.0 | nM | 6.15 |
| CHEMBL317969 | — | EC50 | = | 887.0 | nM | 6.05 |
| CHEMBL330233 | — | EC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL320157 | — | EC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL329490 | — | EC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL329847 | — | EC50 | = | 2170.0 | nM | 5.66 |
| CHEMBL96871 | — | EC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL94369 | — | EC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL432027 | — | EC50 | = | 6200.0 | nM | 5.21 |
| CHEMBL275303 | — | EC50 | = | 11700.0 | nM | 4.93 |