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Assay Detail

CHEMBL714372

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Functional
Agonist activity of compound towards mouse Melanocortin-4 receptor (mMC4R); partial agonist
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Confidence 8 — Homologous single protein target
Curated By Autocuration

Target

Melanocortin receptor 4 (CHEMBL3719)
Type SINGLE PROTEIN
Organism Mus musculus

Publication

Structure-activity relationships of the melanocortin tetrapeptide Ac-His-DPhe-Arg-Trp-NH(2) at the mouse melanocortin receptors: part 2 modifications at the Phe position.
Holder JR, Bauzo RM, Xiang Z, Haskell-Luevano C.
J Med Chem (2002) 45 : 3073 -3081
PubMed 12086493 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 1 8.11 8.11

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL103817 1 8.11

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL103817 EC50 = 7.78 nM 8.11