Assay Detail
Functional
CHEMBL714373
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Agonistic activity evaluated at melanocortin 4 receptor (MC4R) of mouse HEK293 cells
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Design and pharmacology of peptoids and peptide-peptoid hybrids based on the melanocortin agonists core tetrapeptide sequence.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 7 | 6.49 | 8.27 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL214332 | INTERMEDINE | 2.0 | 1 | 8.27 |
| CHEMBL264190 | — | — | 1 | 7.77 |
| CHEMBL138771 | — | — | 1 | 6.58 |
| CHEMBL138212 | — | — | 1 | 6.19 |
| CHEMBL140847 | — | — | 1 | 6.06 |
| CHEMBL343094 | — | — | 1 | 5.96 |
| CHEMBL140324 | — | — | 1 | 4.57 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL214332 | INTERMEDINE | EC50 | = | 5.4 | nM | 8.27 |
| CHEMBL264190 | — | EC50 | = | 17.0 | nM | 7.77 |
| CHEMBL138771 | — | EC50 | = | 260.0 | nM | 6.58 |
| CHEMBL138212 | — | EC50 | = | 640.0 | nM | 6.19 |
| CHEMBL140847 | — | EC50 | = | 880.0 | nM | 6.06 |
| CHEMBL343094 | — | EC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL140324 | — | EC50 | = | 27200.0 | nM | 4.57 |