Assay Detail
Functional
CHEMBL714772
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The concentration required to inhibit cell growth by 50% was measured on human MOLT-4 cells (96h after exposure)
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MOLT-4 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Targeting 5'-deoxy-5'-(methylthio)adenosine phosphorylase by 5'-haloalkyl analogues of 5'-deoxy-5'-(methylthio)adenosine.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 4.67 | 5.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL609198 | — | — | 1 | 5.00 |
| CHEMBL277041 | METHYLTHIOADENOSINE | — | 1 | 4.96 |
| CHEMBL608305 | — | — | 1 | 4.70 |
| CHEMBL611249 | — | — | 1 | 4.60 |
| CHEMBL608307 | — | — | 1 | 4.40 |
| CHEMBL62847 | — | — | 1 | 4.35 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL609198 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL277041 | METHYLTHIOADENOSINE | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL608305 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL611249 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL608307 | — | IC50 | = | 40000.0 | nM | 4.40 |
| CHEMBL62847 | — | IC50 | = | 45000.0 | nM | 4.35 |