Assay Detail
Binding
CHEMBL714858
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Ability to inhibit the matrix metalloprotease-3 by method of Knight et al using the fluorogenic peptide substrate.
32
Total Activities
32
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Selectivity of inhibition of matrix metalloproteases MMP-3 and MMP-2 by succinyl hydroxamates and their carboxylic acid analogues is dependent on P3' group chirality.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 32 | 6.83 | 9.14 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL279786 | BATIMASTAT | 2.0 | 1 | 9.14 |
| CHEMBL347595 | — | — | 1 | 8.36 |
| CHEMBL350231 | — | — | 1 | 8.17 |
| CHEMBL153914 | — | — | 1 | 8.05 |
| CHEMBL349124 | — | — | 1 | 8.00 |
| CHEMBL154317 | — | — | 1 | 7.89 |
| CHEMBL421985 | — | — | 1 | 7.75 |
| CHEMBL157112 | — | — | 1 | 7.72 |
| CHEMBL152592 | — | — | 1 | 7.68 |
| CHEMBL152531 | — | — | 1 | 7.66 |
| CHEMBL153446 | — | — | 1 | 7.60 |
| CHEMBL154551 | — | — | 1 | 7.40 |
| CHEMBL157163 | — | — | 1 | 7.40 |
| CHEMBL436230 | — | — | 1 | 7.32 |
| CHEMBL20154 | — | — | 1 | 7.32 |
| CHEMBL152855 | — | — | 1 | 7.14 |
| CHEMBL345445 | — | — | 1 | 6.56 |
| CHEMBL152805 | — | — | 1 | 6.39 |
| CHEMBL152625 | — | — | 1 | 6.32 |
| CHEMBL154215 | — | — | 1 | 6.25 |
| CHEMBL152267 | — | — | 1 | 6.24 |
| CHEMBL268992 | — | — | 1 | 6.20 |
| CHEMBL349099 | — | — | 1 | 5.55 |
| CHEMBL347594 | — | — | 1 | 5.50 |
| CHEMBL152769 | — | — | 1 | 5.47 |
| CHEMBL414626 | — | — | 1 | 5.30 |
| CHEMBL541456 | — | — | 1 | 5.27 |
| CHEMBL433934 | — | — | 1 | 5.21 |
| CHEMBL156663 | — | — | 1 | 5.07 |
| CHEMBL157048 | — | — | 1 | 5.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL279786 | BATIMASTAT | IC50 | = | 0.73 | nM | 9.14 |
| CHEMBL347595 | — | IC50 | = | 4.4 | nM | 8.36 |
| CHEMBL350231 | — | IC50 | = | 6.8 | nM | 8.17 |
| CHEMBL153914 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL349124 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL154317 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL421985 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL157112 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL152592 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL152531 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL153446 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL154551 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL157163 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL436230 | — | IC50 | = | 48.0 | nM | 7.32 |
| CHEMBL20154 | — | IC50 | = | 48.0 | nM | 7.32 |
| CHEMBL152855 | — | IC50 | = | 73.0 | nM | 7.14 |
| CHEMBL345445 | — | IC50 | = | 275.0 | nM | 6.56 |
| CHEMBL152805 | — | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL152625 | — | IC50 | = | 475.0 | nM | 6.32 |
| CHEMBL154215 | — | IC50 | = | 560.0 | nM | 6.25 |
| CHEMBL152267 | — | IC50 | = | 570.0 | nM | 6.24 |
| CHEMBL268992 | — | IC50 | = | 625.0 | nM | 6.20 |
| CHEMBL349099 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL347594 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL152769 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL414626 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL541456 | — | IC50 | = | 5350.0 | nM | 5.27 |
| CHEMBL433934 | — | IC50 | = | 6100.0 | nM | 5.21 |
| CHEMBL156663 | — | IC50 | = | 8500.0 | nM | 5.07 |
| CHEMBL157048 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL345818 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL156614 | — | IC50 | > | 10000.0 | nM | - |