Assay Detail
Binding
CHEMBL714992
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In vitro inhibition of Matrix metalloprotease-2
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Biaryl ether retrohydroxamates as potent, long-lived, orally bioavailable MMP inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 5.36 | 7.50 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL38851 | — | — | 1 | 7.50 |
| CHEMBL36615 | — | — | 1 | 6.40 |
| CHEMBL41892 | — | — | 1 | 5.23 |
| CHEMBL290067 | — | — | 1 | 5.10 |
| CHEMBL41923 | — | — | 1 | 4.72 |
| CHEMBL43026 | — | — | 1 | 4.46 |
| CHEMBL41067 | — | — | 1 | 4.12 |
| CHEMBL41928 | — | — | 1 | - |
| CHEMBL289108 | — | — | 1 | - |
| CHEMBL41485 | — | — | 1 | - |
| CHEMBL42862 | — | — | 1 | - |
| CHEMBL39358 | — | — | 1 | - |
| CHEMBL39035 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL38851 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL36615 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL41892 | — | IC50 | = | 5900.0 | nM | 5.23 |
| CHEMBL290067 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL41923 | — | IC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL43026 | — | IC50 | = | 35000.0 | nM | 4.46 |
| CHEMBL41067 | — | IC50 | = | 76000.0 | nM | 4.12 |
| CHEMBL41928 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL289108 | — | IC50 | = | 650000.0 | nM | - |
| CHEMBL41485 | — | IC50 | = | 260000.0 | nM | - |
| CHEMBL42862 | — | IC50 | = | 950000.0 | nM | - |
| CHEMBL39358 | — | IC50 | = | 160000.0 | nM | - |
| CHEMBL39035 | — | IC50 | = | 480000.0 | nM | - |