Assay Detail
Binding
CHEMBL714997
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Inhibition of matrix metalloprotease-2 (MMP-2), gelatinase-A
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Dual inhibition of phosphodiesterase 4 and matrix metalloproteinases by an (arylsulfonyl)hydroxamic acid template.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 7.53 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL114116 | — | — | 1 | 8.00 |
| CHEMBL153469 | — | — | 1 | 7.70 |
| CHEMBL44250 | — | — | 1 | 7.70 |
| CHEMBL42521 | — | — | 1 | 7.52 |
| CHEMBL151996 | — | — | 1 | 7.30 |
| CHEMBL44225 | — | — | 1 | 7.30 |
| CHEMBL151249 | — | — | 1 | 7.22 |
| CHEMBL432299 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL114116 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL153469 | — | Ki | = | 20.0 | nM | 7.70 |
| CHEMBL44250 | — | Ki | = | 20.0 | nM | 7.70 |
| CHEMBL42521 | — | Ki | = | 30.0 | nM | 7.52 |
| CHEMBL151996 | — | Ki | = | 50.0 | nM | 7.30 |
| CHEMBL44225 | — | Ki | = | 50.0 | nM | 7.30 |
| CHEMBL151249 | — | Ki | = | 60.0 | nM | 7.22 |
| CHEMBL432299 | — | Ki | > | 10000.0 | nM | - |