Assay Detail
Binding
CHEMBL714999
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Inhibition of Matrix metalloprotease-2
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Evaluation of P1'-diversified phosphinic peptides leads to the development of highly selective inhibitors of MMP-11.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 6.96 | 10.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL75094 | PRINOMASTAT | 3.0 | 1 | 10.30 |
| CHEMBL115774 | — | — | 1 | 7.70 |
| CHEMBL327108 | — | — | 1 | 5.33 |
| CHEMBL324891 | — | — | 1 | 4.52 |
| CHEMBL323885 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL75094 | PRINOMASTAT | Ki | = | 0.05 | nM | 10.30 |
| CHEMBL115774 | — | Ki | = | 20.0 | nM | 7.70 |
| CHEMBL327108 | — | Ki | = | 4650.0 | nM | 5.33 |
| CHEMBL324891 | — | Ki | = | 30000.0 | nM | 4.52 |
| CHEMBL323885 | — | Ki | = | 200000.0 | nM | - |