Assay Detail
Binding
CHEMBL715001
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Inhibition of Matrix metalloprotease-2
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Selectivity of inhibition of matrix metalloproteases MMP-3 and MMP-2 by succinyl hydroxamates and their carboxylic acid analogues is dependent on P3' group chirality.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 7.92 | 9.24 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL19611 | ILOMASTAT | 2.0 | 1 | 9.24 |
| CHEMBL151741 | — | — | 1 | 7.52 |
| CHEMBL152104 | — | — | 1 | 7.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL19611 | ILOMASTAT | Ki | = | 0.57 | nM | 9.24 |
| CHEMBL151741 | — | Ki | = | 30.0 | nM | 7.52 |
| CHEMBL152104 | — | Ki | = | 100.0 | nM | 7.00 |