Assay Detail
Binding
CHEMBL715003
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Inhibition of human matrix metalloprotease-2
28
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Protease inhibitors: synthesis of matrix metalloproteinase and bacterial collagenase inhibitors incorporating 5-amino-2-mercapto-1,3,4-thiadiazole zinc binding functions.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 28 | 5.06 | 10.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL75094 | PRINOMASTAT | 3.0 | 1 | 10.10 |
| CHEMBL3142607 | — | — | 1 | 5.70 |
| CHEMBL3142606 | — | — | 1 | 5.40 |
| CHEMBL3142594 | — | — | 1 | 5.30 |
| CHEMBL3142592 | — | — | 1 | 5.22 |
| CHEMBL3142605 | — | — | 1 | 5.16 |
| CHEMBL3142590 | — | — | 1 | 5.10 |
| CHEMBL3142596 | — | — | 1 | 5.10 |
| CHEMBL3142600 | — | — | 1 | 5.00 |
| CHEMBL3142601 | — | — | 1 | 4.96 |
| CHEMBL3142614 | — | — | 1 | 4.92 |
| CHEMBL3142610 | — | — | 1 | 4.92 |
| CHEMBL3142611 | — | — | 1 | 4.89 |
| CHEMBL3142626 | — | — | 1 | 4.82 |
| CHEMBL3142589 | — | — | 1 | 4.82 |
| CHEMBL3142618 | — | — | 1 | 4.80 |
| CHEMBL3142625 | — | — | 1 | 4.80 |
| CHEMBL3142627 | — | — | 1 | 4.77 |
| CHEMBL3142593 | — | — | 1 | 4.77 |
| CHEMBL3142602 | — | — | 1 | 4.75 |
| CHEMBL3142588 | — | — | 1 | 4.75 |
| CHEMBL3142615 | — | — | 1 | 4.70 |
| CHEMBL3142598 | — | — | 1 | 4.62 |
| CHEMBL3142591 | — | — | 1 | 4.48 |
| CHEMBL3142612 | — | — | 1 | 4.46 |
| CHEMBL3142599 | — | — | 1 | 4.44 |
| CHEMBL3142608 | — | — | 1 | 4.40 |
| CHEMBL3142613 | — | — | 1 | 4.39 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL75094 | PRINOMASTAT | Ki | = | 0.08 | nM | 10.10 |
| CHEMBL3142607 | — | Ki | = | 2000.0 | nM | 5.70 |
| CHEMBL3142606 | — | Ki | = | 4000.0 | nM | 5.40 |
| CHEMBL3142594 | — | Ki | = | 5000.0 | nM | 5.30 |
| CHEMBL3142592 | — | Ki | = | 6000.0 | nM | 5.22 |
| CHEMBL3142605 | — | Ki | = | 7000.0 | nM | 5.16 |
| CHEMBL3142590 | — | Ki | = | 8000.0 | nM | 5.10 |
| CHEMBL3142596 | — | Ki | = | 8000.0 | nM | 5.10 |
| CHEMBL3142600 | — | Ki | = | 10000.0 | nM | 5.00 |
| CHEMBL3142601 | — | Ki | = | 11000.0 | nM | 4.96 |
| CHEMBL3142614 | — | Ki | = | 12000.0 | nM | 4.92 |
| CHEMBL3142610 | — | Ki | = | 12000.0 | nM | 4.92 |
| CHEMBL3142611 | — | Ki | = | 13000.0 | nM | 4.89 |
| CHEMBL3142626 | — | Ki | = | 15000.0 | nM | 4.82 |
| CHEMBL3142589 | — | Ki | = | 15000.0 | nM | 4.82 |
| CHEMBL3142618 | — | Ki | = | 16000.0 | nM | 4.80 |
| CHEMBL3142625 | — | Ki | = | 16000.0 | nM | 4.80 |
| CHEMBL3142627 | — | Ki | = | 17000.0 | nM | 4.77 |
| CHEMBL3142593 | — | Ki | = | 17000.0 | nM | 4.77 |
| CHEMBL3142602 | — | Ki | = | 18000.0 | nM | 4.75 |
| CHEMBL3142588 | — | Ki | = | 18000.0 | nM | 4.75 |
| CHEMBL3142615 | — | Ki | = | 20000.0 | nM | 4.70 |
| CHEMBL3142598 | — | Ki | = | 24000.0 | nM | 4.62 |
| CHEMBL3142591 | — | Ki | = | 33000.0 | nM | 4.48 |
| CHEMBL3142612 | — | Ki | = | 35000.0 | nM | 4.46 |
| CHEMBL3142599 | — | Ki | = | 36000.0 | nM | 4.44 |
| CHEMBL3142608 | — | Ki | = | 40000.0 | nM | 4.40 |
| CHEMBL3142613 | — | Ki | = | 41000.0 | nM | 4.39 |