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Assay Detail

CHEMBL715010

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Binding
Inhibitory activity against Matrix metalloprotease-2
ChEMBL ↗
64
Total Activities
64
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Expert

Target

72 kDa type IV collagenase (CHEMBL333) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Carbonic anhydrase and matrix metalloproteinase inhibitors: sulfonylated amino acid hydroxamates with MMP inhibitory properties act as efficient inhibitors of CA isozymes I, II, and IV, and N-hydroxysulfonamides inhibit both these zinc enzymes.
Scozzafava A, Supuran CT.
J Med Chem (2000) 43 : 3677 -3687
PubMed 11020282 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 64 6.95 9.15

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL123775 — — 1 9.15
CHEMBL293503 — — 1 9.15
CHEMBL332755 — — 1 9.10
CHEMBL306726 — — 1 9.10
CHEMBL340461 — — 1 9.10
CHEMBL123463 — — 1 9.05
CHEMBL122836 — — 1 8.85
CHEMBL122711 — — 1 8.85
CHEMBL432223 — — 1 8.82
CHEMBL55110 — — 1 8.82
CHEMBL262676 — — 1 8.82
CHEMBL331311 — — 1 8.72
CHEMBL330857 — — 1 8.62
CHEMBL304281 — — 1 8.54
CHEMBL123041 — — 1 8.49
CHEMBL122719 — — 1 8.43
CHEMBL122831 — — 1 8.43
CHEMBL441084 — — 1 8.41
CHEMBL331342 — — 1 8.00
CHEMBL311336 — — 1 7.96
CHEMBL440714 — — 1 7.92
CHEMBL450327 — — 1 7.89
CHEMBL122651 — — 1 7.82
CHEMBL332120 — — 1 7.82
CHEMBL316169 — — 1 7.82
CHEMBL82868 — — 1 7.75
CHEMBL293774 — — 1 7.75
CHEMBL120049 — — 1 7.41
CHEMBL331669 — — 1 7.40
CHEMBL332406 — — 1 7.39

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL123775 — Ki = 0.7 nM 9.15
CHEMBL293503 — Ki = 0.7 nM 9.15
CHEMBL306726 — Ki = 0.8 nM 9.10
CHEMBL340461 — Ki = 0.8 nM 9.10
CHEMBL332755 — Ki = 0.8 nM 9.10
CHEMBL123463 — Ki = 0.9 nM 9.05
CHEMBL122836 — Ki = 1.4 nM 8.85
CHEMBL122711 — Ki = 1.4 nM 8.85
CHEMBL432223 — Ki = 1.5 nM 8.82
CHEMBL55110 — Ki = 1.5 nM 8.82
CHEMBL262676 — Ki = 1.5 nM 8.82
CHEMBL331311 — Ki = 1.9 nM 8.72
CHEMBL330857 — Ki = 2.4 nM 8.62
CHEMBL304281 — Ki = 2.9 nM 8.54
CHEMBL123041 — Ki = 3.2 nM 8.49
CHEMBL122719 — Ki = 3.7 nM 8.43
CHEMBL122831 — Ki = 3.7 nM 8.43
CHEMBL441084 — Ki = 3.9 nM 8.41
CHEMBL331342 — Ki = 10.0 nM 8.00
CHEMBL311336 — Ki = 11.0 nM 7.96
CHEMBL440714 — Ki = 12.0 nM 7.92
CHEMBL450327 — Ki = 13.0 nM 7.89
CHEMBL122651 — Ki = 15.0 nM 7.82
CHEMBL332120 — Ki = 15.0 nM 7.82
CHEMBL316169 — Ki = 15.0 nM 7.82
CHEMBL82868 — Ki = 18.0 nM 7.75
CHEMBL293774 — Ki = 18.0 nM 7.75
CHEMBL120049 — Ki = 39.0 nM 7.41
CHEMBL331669 — Ki = 40.0 nM 7.40
CHEMBL332406 — Ki = 41.0 nM 7.39
CHEMBL123167 — Ki = 44.0 nM 7.36
CHEMBL123443 — Ki = 62.0 nM 7.21
CHEMBL333248 — Ki = 66.0 nM 7.18
CHEMBL332429 — Ki = 69.0 nM 7.16
CHEMBL332858 — Ki = 75.0 nM 7.12
CHEMBL121916 — Ki = 82.0 nM 7.09
CHEMBL123382 — Ki = 84.0 nM 7.08
CHEMBL333896 — Ki = 87.0 nM 7.06
CHEMBL333532 — Ki = 90.0 nM 7.05
CHEMBL83508 — Ki = 110.0 nM 6.96
CHEMBL332362 — Ki = 120.0 nM 6.92
CHEMBL122925 — Ki = 900.0 nM 6.05
CHEMBL123233 — Ki = 9000.0 nM 5.05
CHEMBL122950 — Ki = 11000.0 nM 4.96
CHEMBL122868 — Ki = 14000.0 nM 4.85
CHEMBL122109 — Ki = 14000.0 nM 4.85
CHEMBL331114 — Ki = 14000.0 nM 4.85
CHEMBL123105 — Ki = 15000.0 nM 4.82
CHEMBL332439 — Ki = 19000.0 nM 4.72
CHEMBL123064 — Ki = 21000.0 nM 4.68