Assay Detail
Binding
CHEMBL715018
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Inhibitory activity against type I methionine aminopeptidase from Saccharomyces cerevisiae
43
Total Activities
43
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Target
Methionine aminopeptidase 1 (CHEMBL2526) ↗| Type | SINGLE PROTEIN |
| Organism | Saccharomyces cerevisiae S288c |
Publication
Discovery and structural modification of inhibitors of methionine aminopeptidases from Escherichia coli and Saccharomyces cerevisiae.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 43 | 5.71 | 6.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL328350 | — | — | 1 | 6.85 |
| CHEMBL86427 | — | — | 1 | 6.70 |
| CHEMBL89612 | — | — | 1 | 6.51 |
| CHEMBL315098 | — | — | 1 | 6.50 |
| CHEMBL91372 | — | — | 1 | 6.50 |
| CHEMBL316308 | — | — | 1 | 6.47 |
| CHEMBL92374 | — | — | 1 | 6.46 |
| CHEMBL314448 | — | — | 1 | 6.42 |
| CHEMBL90048 | — | — | 1 | 6.42 |
| CHEMBL88865 | — | — | 1 | 6.41 |
| CHEMBL88864 | — | — | 1 | 6.31 |
| CHEMBL88599 | — | — | 1 | 6.26 |
| CHEMBL313650 | — | — | 1 | 6.21 |
| CHEMBL89386 | — | — | 1 | 6.11 |
| CHEMBL313629 | — | — | 1 | 6.11 |
| CHEMBL90827 | — | — | 1 | 6.09 |
| CHEMBL90619 | — | — | 1 | 6.05 |
| CHEMBL315270 | — | — | 1 | 5.99 |
| CHEMBL315903 | — | — | 1 | 5.76 |
| CHEMBL432379 | — | — | 1 | 5.52 |
| CHEMBL328363 | — | — | 1 | 5.47 |
| CHEMBL327579 | — | — | 1 | 5.47 |
| CHEMBL90049 | — | — | 1 | 5.33 |
| CHEMBL328555 | — | — | 1 | 5.31 |
| CHEMBL315556 | — | — | 1 | 5.31 |
| CHEMBL89671 | — | — | 1 | 5.16 |
| CHEMBL89269 | — | — | 1 | 5.00 |
| CHEMBL446935 | — | — | 1 | 4.96 |
| CHEMBL420981 | — | — | 1 | 4.82 |
| CHEMBL313951 | — | — | 1 | 4.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL328350 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL86427 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL89612 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL315098 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL91372 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL316308 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL92374 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL314448 | — | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL90048 | — | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL88865 | — | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL88864 | — | IC50 | = | 490.0 | nM | 6.31 |
| CHEMBL88599 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL313650 | — | IC50 | = | 620.0 | nM | 6.21 |
| CHEMBL89386 | — | IC50 | = | 780.0 | nM | 6.11 |
| CHEMBL313629 | — | IC50 | = | 770.0 | nM | 6.11 |
| CHEMBL90827 | — | IC50 | = | 820.0 | nM | 6.09 |
| CHEMBL90619 | — | IC50 | = | 890.0 | nM | 6.05 |
| CHEMBL315270 | — | IC50 | = | 1030.0 | nM | 5.99 |
| CHEMBL315903 | — | IC50 | = | 1740.0 | nM | 5.76 |
| CHEMBL432379 | — | IC50 | = | 3020.0 | nM | 5.52 |
| CHEMBL327579 | — | IC50 | = | 3350.0 | nM | 5.47 |
| CHEMBL328363 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL90049 | — | IC50 | = | 4670.0 | nM | 5.33 |
| CHEMBL328555 | — | IC50 | = | 4920.0 | nM | 5.31 |
| CHEMBL315556 | — | IC50 | = | 4860.0 | nM | 5.31 |
| CHEMBL89671 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL89269 | — | IC50 | = | 9900.0 | nM | 5.00 |
| CHEMBL446935 | — | IC50 | = | 10900.0 | nM | 4.96 |
| CHEMBL420981 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL313951 | — | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL314521 | — | IC50 | = | 32800.0 | nM | 4.48 |
| CHEMBL89523 | — | IC50 | = | 53700.0 | nM | 4.27 |
| CHEMBL91437 | — | IC50 | = | 62000.0 | nM | 4.21 |
| CHEMBL2370141 | — | IC50 | = | 95140.0 | nM | 4.02 |
| CHEMBL32838 | FUMAGILLIN | IC50 | > | 100000.0 | nM | - |
| CHEMBL89687 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL316339 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL316138 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL329455 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL329320 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL313915 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL88489 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL89609 | — | IC50 | > | 100000.0 | nM | - |